Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2022; 28(34): 5076-5085
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.5076
Gastrointestinal tumors in transplantation: Two case reports and review of literature
Romain Stammler, Dany Anglicheau, Bruno Landi, Tchao Meatchi, Emilia Ragot, Eric Thervet, Hélène Lazareth
Romain Stammler, Eric Thervet, Hélène Lazareth, Department of Nephrology, Georges Pompidou European Hospital, Paris 75015, France
Dany Anglicheau, Department of Renal Transplantation, Necker-Enfants Malades Institute, French National Institutes of Health and Medical Research U1151, Paris 75015, France
Dany Anglicheau, Bruno Landi, Eric Thervet, Hélène Lazareth, Université Paris Cité, Assistance Publique des Hôpitaux de Paris, Paris 75001, France
Bruno Landi, Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, Paris 75015, France
Tchao Meatchi, Department of Pathology, Georges Pompidou European Hospital, Paris 75015, France
Emilia Ragot, Department of Digestive Surgery, Georges Pompidou European Hospital, Paris 75015, France
Author contributions: Stammler R and Lazareth H designed the study; Stammler R, Lazareth H, Anglicheau D, Meatchi T, Ragot E, and Thervet E investigated the patients and collected the data; Stammler R, Lazareth H, and Landi B interpreted the data and wrote the manuscript; all authors revised the manuscript and approved the final version.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: The authors have no conflicts of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hélène Lazareth, MD, PhD, Doctor, Department of Nephrology, Georges Pompidou European Hospital, 20, rue Leblanc, Paris 75015, France.
Received: March 7, 2022
Peer-review started: March 7, 2022
First decision: April 5, 2022
Revised: April 19, 2022
Accepted: August 6, 2022
Article in press: August 6, 2022
Published online: September 14, 2022
Core Tip

Core Tip: Although a well-known higher risk of neoplasm has been described among renal transplant recipients (RTRs), few cases of gastrointestinal stromal tumors (GISTs) have been reported. We describe 2 cases of gastric GIST among RTRs and provide a review of the literature. We report 16 patients with a median age of 59.5 years, and 69% were male. No patient displayed metastasis at diagnosis. Time from transplantation to diagnosis varied between 5 mo and 21 years. Histopathology revealed high risk of progression (43%). Death increased to 29%. Surgical treatment was commonly performed (94%). The use of adjuvant therapy was uncommon (19%).