Miao YD, Tang XL, Wang JT, Mi DH. Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis. World J Gastroenterol 2022; 28(30): 4221-4226 [PMID: 36157115 DOI: 10.3748/wjg.v28.i30.4221]
Corresponding Author of This Article
Deng-Hai Mi, MD, Chief Doctor, Dean, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 14, 2022; 28(30): 4221-4226 Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4221
Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis
Yan-Dong Miao, Xiao-Long Tang, Jiang-Tao Wang, Deng-Hai Mi
Yan-Dong Miao, Xiao-Long Tang, Jiang-Tao Wang, Deng-Hai Mi, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China
Yan-Dong Miao, Jiang-Tao Wang, Yantai Affiliated Hospital of Binzhou Medical University, The Second Clinical Medical College of Binzhou Medical University, Yantai 264000, Shandong Province, China
Deng-Hai Mi, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Author contributions: Mi DH and Miao YD designed the research; Miao YD wrote this comment; Miao YD and Tang XL performed data analysis and prepared the tables and figures; Wang JT downloaded the data; Mi DH reviewed the manuscript; Miao YD and Tang XL contributed equally to this work; and all authors approved the final manuscript.
Supported bythe Special Plan for Condition Construction of Gansu Provincial Scientific Research Institutes, No. 20JR10RA432.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deng-Hai Mi, MD, Chief Doctor, Dean, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com
Received: July 30, 2021 Peer-review started: July 30, 2021 First decision: August 19, 2021 Revised: August 22, 2021 Accepted: July 18, 2022 Article in press: July 18, 2022 Published online: August 14, 2022 Processing time: 376 Days and 7.1 Hours
Core Tip
Core Tip: We found that the expression of angiogenesis markers was significantly higher in tumor tissues than in normal tissues in both unpaired and paired hepatocellular carcinoma (HCC) samples. These angiogenesis markers are mainly involved in regulating the activation of the EMT pathway, the RAS/mitogen-activated protein kinase and receptor tyrosine kinase pathways, and the tuberous sclerosis protein/mammalian target of rapamycin pathway. In addition, there was a significant difference in overall survival between HCC patients with high and low expression of angiopoietin-2 (ANGPT2), placental growth factor (PGF), vascular endothelial growth factor A (VEGFA), and VEGFD. Disease free survival was significantly shorter in HCC patients with high ANGPT2, PGF, and VEGFA expression than in those with low ANGPT2, PGF, and VEGFA expression.
