Retrospective Cohort Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2022; 28(30): 4102-4119
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4102
Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease
Ling-Ya Yao, Bu-Le Shao, Feng Tian, Mei Ye, Yu-Qin Li, Xiao-Lei Wang, Lin Wang, Shao-Qi Yang, Xiao-Ping Lv, Yan Jia, Xue-Hong Wang, Xiao-Qi Zhang, Yan-Ling Wei, Qian Cao
Ling-Ya Yao, Bu-Le Shao, Qian Cao, Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Feng Tian, Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Mei Ye, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei Province, China
Yu-Qin Li, Department of Gastroenterology, Bethune First Affiliated Hospital of Jilin University, Changchun 130000, Jilin Province, China
Xiao-Lei Wang, Department of Gastroenterology, Shanghai 10th People's Hospital, Tongji University, Shanghai 200072, China
Lin Wang, Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361000, Fujian Province, China
Shao-Qi Yang, Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Xiao-Ping Lv, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Yan Jia, Department of Gastroenterology, The 7th Medical Center of Chinese PLA General Hospital, Beijing 100000, China
Xue-Hong Wang, Department of Gastroenterology, Second Xiangya Hospital, Changsha 410011, Hunan Province, China
Xiao-Qi Zhang, Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing 210000, Jiangsu Province, China
Yan-Ling Wei, Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing 400000, China
Author contributions: Cao Q formulated the research idea; Yao LY developed the study protocol; Yao LY, Tian F, Ye M, Li YQ, Wang XL, Wang L, Yang SQ, Lv XP, Jia Y, Wang XH, Zhang XQ and Wei YL conducted the patient identification and data collection; Shao BL and Yao LY conducted the data analysis; Yao LY, Shao BL and Cao Q developed the manuscript; and all authors have read and approve the final manuscript.
Institutional review board statement: The study protocol was reviewed and approved by Sir Run Run Shaw Hospital, College of Medicine Zhejiang University Institutional Review Board with approval for all hospitals involved in the study, No. 20210714-31.
Informed consent statement: The requirement for patient informed consent was waived due to the retrospective nature of this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Qian Cao, PhD, Chief Doctor, Chief Physician, Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, No. 3 East Qingchun Road, Shangcheng District, Hangzhou 310016, Zhejiang Province, China.
Received: April 15, 2022
Peer-review started: April 15, 2022
First decision: May 12, 2022
Revised: May 26, 2022
Accepted: July 20, 2022
Article in press: July 20, 2022
Published online: August 14, 2022
Core Tip

Core Tip: Prescriptions of immunosuppressants and infliximab (IFX) increased in parallel with steady or decreasing prescriptions of 5-aminosalicylates and corticosteroids in Chinese patients with inflammatory bowel disease. Furthermore, a switching profile from conventional drugs to IFX was observed in patients with Crohn's disease. This is the first multicenter cohort study to depict temporal trends in long-term medication uses and periodic changes in treatment paradigms in the Chinese population, which may provide evidence for clinical practice in the foreseeable future.