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World J Gastroenterol. Aug 14, 2022; 28(30): 4044-4052
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4044
Current perspectives on the role of liver transplantation for Langerhans cell histiocytosis: A narrative review
Jagadeesh Menon, Ashwin Rammohan, Mukul Vij, Naresh Shanmugam, Mohamed Rela
Jagadeesh Menon, Ashwin Rammohan, Mukul Vij, Naresh Shanmugam, Mohamed Rela, Institute of Liver Disease & Transplantation, Dr. Rela Institute & Medical Centre, Bharath Institute of Higher Education & Research, Chennai 600044, India
Author contributions: Menon J, Rammohan A, and Shanmugam N contributed to conception and design; Rammohan A, Menon J, and Rela M contributed to the acquisition, analysis, and interpretation of data; Menon J, Rammohan A, Vij M, and Shanmugam N drafted the article, and revised it critically for important intellectual content; Rela M gave the final approval of the version to be published.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashwin Rammohan, FACS, FRCS, MCh, Attending Doctor, Institute of Liver Disease & Transplantation, Dr. Rela Institute & Medical Centre, Bharath Institute of Higher Education & Research, CLC Works Road, Chromepet, Chennai 600044, India. ashwinrammohan@gmail.com
Received: January 9, 2022
Peer-review started: January 9, 2022
First decision: March 8, 2022
Revised: March 30, 2022
Accepted: July 19, 2022
Article in press: July 19, 2022
Published online: August 14, 2022
Core Tip

Core Tip: Involvement of the liver in Langerhans cell histiocytosis (LCH) is considered a high-risk disease and the management algorithm needs to factor in the malignancy and the severity of liver disease. Liver transplantation (LT) is usually offered to LCH patients in remission with decompensated liver disease. However, given the paucity of currently available literature, the role of LT in LCH remains undefined. There is hence a need for large collaborative, multicentre studies to provide recommendations on the management algorithm for LCH.