Basic Study
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World J Gastroenterol. Jul 21, 2022; 28(27): 3455-3475
Published online Jul 21, 2022. doi: 10.3748/wjg.v28.i27.3455
Associations of gut microbiota with dyslipidemia based on sex differences in subjects from Northwestern China
Lei Guo, Yang-Yang Wang, Ji-Han Wang, He-Ping Zhao, Yan Yu, Guo-Dong Wang, Kun Dai, Yu-Zhu Yan, Yan-Jie Yang, Jing Lv
Lei Guo, Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China
Yang-Yang Wang, School of Electronics and Information, Northwestern Polytechnical University, Xi'an 710129, Shaanxi Province, China
Ji-Han Wang, Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, Shaanxi Province, China
He-Ping Zhao, Yan Yu, Yu-Zhu Yan, Jing Lv, Department of Clinical Laboratory, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China
Guo-Dong Wang, Department of Quality Control, Xi’an Mental Health Center, Xi'an 710100, Shaanxi Province, China
Kun Dai, Department of Clinical Laboratory, Yanliang Railway Hospital of Xi’an, Xi'an 710089, Shaanxi Province, China
Yan-Jie Yang, Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Author contributions: All the authors solely contributed to this article; Guo L and Lv J searched and reviewed published articles, interpreted data, constructed tables, drafted the article, and made substantial contributions to the conception and design of this study; Wang YY, Wang JH and Yan YZ conducted the experiments, performed sequencing analysis and constructed the figures; Wang YY, Wang JH and Wang GD performed statistical analysis; Zhao HP, Yu Y and Dai K constructed the figures and tables; Yang YJ contributed to the conception of the study; and all authors critically reviewed the manuscript, and approved the final version to be published.
Supported by Youth Program of Xi'an Municipal Health Commission of China, No. 2022qn07; General Program of Xi'an Municipal Health Commission of China, No. 2020ms14; and National Natural Science Foundation of China, No. 81702067.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Honghui Hospital, Xi’an Jiaotong University, No. 201801022.
Informed consent statement: All study participants provided informed consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The raw data supporting the conclusions of this article available from the corresponding author at
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jing Lv, MD, Doctor, Department of Clinical Laboratory, Honghui Hospital, Xi'an Jiaotong University, No. 555 You Yi Dong Road, Xi'an 710054, Shaanxi Province, China.
Received: February 18, 2022
Peer-review started: February 18, 2022
First decision: May 9, 2022
Revised: May 17, 2022
Accepted: June 20, 2022
Article in press: June, 20, 2022
Published online: July 21, 2022
Core Tip

Core Tip: Dyslipidemia is the circulating lipid expression of metabolic syndrome, and alterations of gut microbiota (GM) are indicated to participate in the pathogenesis of dyslipidemia; however, little evidence was found in the literature on sex differences for these associations. Our results demonstrated the GM features in different dyslipidemia subgroups in females and males, suggesting a complex interaction between GM and lipid metabolism. Our observations may provide new evidence that different GM taxa may be associated with distinct lipids, and that GM may affect specific aspects of lipid metabolism. More studies are required to propose specific taxa that have the potential to ameliorate dyslipidemia.