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Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2022; 28(2): 176-187
Published online Jan 14, 2022. doi: 10.3748/wjg.v28.i2.176
Nanotheranostics: A powerful next-generation solution to tackle hepatocellular carcinoma
Rusdina Bte Ladju, Zulvikar Syambani Ulhaq, Gita Vita Soraya
Rusdina Bte Ladju, Department of Anatomic Pathology, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Zulvikar Syambani Ulhaq, Department of Biochemistry, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University, Malang 65151, Indonesia
Zulvikar Syambani Ulhaq, National Research and Innovation Agency, Central Jakarta 10340, Indonesia
Gita Vita Soraya, Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Gita Vita Soraya, Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia
Author contributions: Ulhaq ZS and Soraya GV conceptualized the manuscript; Ladju RB wrote the first draft of the manuscript; all authors conducted the literature review and the writing and editing of the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gita Vita Soraya, MD, PhD, Assistant Professor, Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Jl Perintis Kemerdekaan Km 10, Makassar 90245, Indonesia. gitavitasoraya@unhas.ac.id
Received: March 18, 2021
Peer-review started: March 18, 2021
First decision: July 3, 2021
Revised: July 15, 2021
Accepted: December 31, 2021
Article in press: December 31, 2021
Published online: January 14, 2022
Processing time: 299 Days and 1.7 Hours
Core Tip

Core Tip: Hepatocellular carcinoma (HCC) is a global epidemic burden. The high mortality rate is mostly due to late diagnosis and complexity of treatment. Nanotheranostics is a potential approach for HCC management. We herein discuss the challenges of HCC management, the advancement of nanotheranostics in cancer, and the potential role of nanotheranostics to address the current challenges in HCC management.