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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2022; 28(16): 1671-1680
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1671
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1671
Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19
Ali Madian, Haitham A Azeem Aly, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Assiut, Assiut 71524, Egypt
Ahmed Eliwa, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Cairo, Cairo 11754, Egypt
Hytham Abdalla, Department of Chest Diseases, Faculty of Medicine, Al-Azhar University-Assiut, Assiut 71524, Egypt
Author contributions: Madian A was responsible for the study conception and design, the data acquisition, analysis and interpretation, the statistical analysis, and writing of the first draft of the manuscript; Eliwa A and Abdalla H contributed to the data collection; Azeem HA reviewed the manuscript and provided critical scientific input; all authors approved the final manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Informed consent statement: No informed consent was required, as patient identity is not revealed in the retrospective analysis.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at a.madian@azhar.edu.eg .
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ali Madian, MD, MSc, Lecturer, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Assiut, Assiut 71524, Egypt. a.madian@azhar.edu.eg
Received: November 16, 2021
Peer-review started: November 16, 2021
First decision: January 11, 2022
Revised: January 21, 2022
Accepted: March 16, 2022
Article in press: March 16, 2022
Published online: April 28, 2022
Peer-review started: November 16, 2021
First decision: January 11, 2022
Revised: January 21, 2022
Accepted: March 16, 2022
Article in press: March 16, 2022
Published online: April 28, 2022
Core Tip
Core Tip: Aspartate transferase-to-platelet ratio index-plus can be used to predict the severity of coronavirus disease 2019. The performance of the model for mortality was very good, with an area under the receiver operating curve of 0.90. This new prediction model could help in estimating the risk of mortality and may, therefore, assist in triaging patients. Moreover, our study confirmed that an aspartate transferase-dominant pattern, diabetes mellites, leukocytosis, and increased ferritin levels are associated with fatal outcomes.