Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2022; 28(15): 1574-1587
Published online Apr 21, 2022. doi: 10.3748/wjg.v28.i15.1574
Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study
Zi-Bo Yuan, Hong-Bo Fang, Quan-Kai Feng, Tao Li, Jie Li
Zi-Bo Yuan, Hong-Bo Fang, Quan-Kai Feng, Tao Li, Jie Li, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zi-Bo Yuan, Hong-Bo Fang, Quan-Kai Feng, Jie Li, Henan Research Centre for Organ Transplantation, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Yuan ZB contributed to collect data and draft the manuscript; Fang HB contributed to data analysis; Feng QK and Li T contributed to clinical advice and follow-up survey; Li J contributed to the conception and critically revised the manuscript; all authors read and agreed the final manuscript to be published.
Supported by Medical Science and Technology Project of Henan Province, No. SBGJ2018024.
Institutional review board statement: The study was approved by the Scientific Research and Clinical Trial Ethics Committee of the First Affiliated Hospital of Zhengzhou University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We declare that they have no conflicting interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Li, MD, PhD, Director, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou 450052, Henan Province, China. ljljdoctor@126.com
Received: November 17, 2021
Peer-review started: November 17, 2021
First decision: January 9, 2022
Revised: January 18, 2022
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: April 21, 2022
Processing time: 148 Days and 21.1 Hours
Core Tip

Core Tip: With this 8-year retrospective study, we aimed to investigate the clinical characteristics, analyse the prognostic factors, and discuss therapeutic strategies for patients with recurrent intrahepatic cholangiocarcinoma (ICC) after hepatectomy. Multivariate analysis showed that alcohol consumption [hazard ratio (HR) = 4.64, 95% confidence interval (CI): 1.53-14.04, P = 0.007] and disease-free survival < 6 mo (HR=3.47, 95%CI: 1.59-7.60, P = 0.002) were independent risk factors for cumulative survival for patients with recurrence, while treatment after recurrence (HR=0.21, 95%CI: 0.08-0.55, P = 0.001) was an independent protective factor. We propose that multimodality therapy should be developed to improve long-term outcomes through the combined approach of local therapy, chemotherapy, targeted therapy, and immunotherapy.