Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2022; 28(12): 1226-1238
Published online Mar 28, 2022. doi: 10.3748/wjg.v28.i12.1226
Published online Mar 28, 2022. doi: 10.3748/wjg.v28.i12.1226
Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice
Nadia Marascio, Angela Quirino, Giovanni Matera, Maria Carla Liberto, Department of Health Sciences, Unit of Microbiology, University “Magna Graecia” of Catanzaro, Catanzaro 88100, Italy
Salvatore Rotundo, Chiara Costa, Alessandro Russo, Enrico Maria Trecarichi, Carlo Torti, Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, "Magna Graecia" University of Catanzaro, Catanzaro 88100, Italy
Author contributions: Marascio N, Rotundo S, and Torti C, performed the conception, drafted the article and making critical revisions; Quirino A, Matera G, Liberto MC, Costa C, Russo A, and Trecarichi EM, maked critical revision and contributed for important intellectual contents; all authors approved the final version.
Supported by PON Research and Innovation 2014-2020 (Nadia Marascio) , Attraction and International Mobility programme, No. Proposal Code_ Activity AIM1879147_1.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlo Torti, FRSM, Professor, Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, "Magna Graecia" University of Catanzaro, Loc. Germaneto, Viale Europa, Catanzaro 88100, Italy. torti@unicz.it
Received: November 5, 2021
Peer-review started: November 5, 2021
First decision: December 26, 2021
Revised: January 6, 2022
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: March 28, 2022
Peer-review started: November 5, 2021
First decision: December 26, 2021
Revised: January 6, 2022
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: March 28, 2022
Core Tip
Core Tip: Hepatitis E virus (HEV) and Hepatitis C virus (HCV) are both RNA viruses characterized by greater variability than DNA viruses and mainly infect the liver. Despite these similarities, the two viruses have different species barriers and disease progression. Coinfection with particular HCV and HEV types could aggravate hepatic and/or extrahepatic diseases, taking into account virus–host interactions between the two viruses during viral replication.