Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Peer-review started: December 8, 2020
First decision: December 31, 2020
Revised: January 11, 2021
Accepted: February 1, 2021
Article in press: February 1, 2021
Published online: March 7, 2021
Core Tip: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has become a global public health crisis. Liver impairment is frequent in COVID-19 regardless of whether it is combined with hepatitis B virus (HBV) infection. Currently, there is no evidence to suggest that HBV increases susceptibility to SARS-CoV-2. HBV and SARS-CoV-2 coinfection does not increase the risk of severity and outcome of COVID-19. Nucleoside analogs are recommended due to the risk of HBV reactivation in COVID-19.