Lapaquette P, Bizeau JB, Acar N, Bringer MA. Reciprocal interactions between gut microbiota and autophagy. World J Gastroenterol 2021; 27(48): 8283-8301 [PMID: 35068870 DOI: 10.3748/wjg.v27.i48.8283]
Corresponding Author of This Article
Marie-Agnès Bringer, PhD, Academic Research, Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Centre INRAE, 17 rue Sully, Dijon 21000, France. marie-agnes.bringer@inrae.fr
Research Domain of This Article
Microbiology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 28, 2021; 27(48): 8283-8301 Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8283
Reciprocal interactions between gut microbiota and autophagy
Pierre Lapaquette, Jean-Baptiste Bizeau, Niyazi Acar, Marie-Agnès Bringer
Pierre Lapaquette, UMR PAM A 02.102, University Bourgogne Franche-Comté, Agrosup Dijon, Dijon 21000, France
Jean-Baptiste Bizeau, Niyazi Acar, Marie-Agnès Bringer, Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon 21000, France
Author contributions: Lapaquette P and Bringer MA wrote the paper; Bizeau JB and Acar N revised the manuscript.
Supported byAgence Nationale de la Recherche, No. ANR-11-LABX-0021-01; French “Investissements d’Avenir” program, project ISITE-BFC, No. ANR-15-IDEX-0003; Conseil Régional de Bourgogne, Franche-Comté, No. RECH-E1INV-000131-0-EarlEAT; Institut Carnot Qualiment, INPROBIAUS grant; and FEDER (European Funding for Regional Economic Development), EARLEAT, PO FEDER-FSE Bourgogne 2014-2020 BG 0027905 BG 0027810.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marie-Agnès Bringer, PhD, Academic Research, Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Centre INRAE, 17 rue Sully, Dijon 21000, France. marie-agnes.bringer@inrae.fr
Received: June 18, 2021 Peer-review started: June 18, 2021 First decision: August 19, 2021 Revised: September 9, 2021 Accepted: December 2, 2021 Article in press: December 7, 2021 Published online: December 28, 2021 Processing time: 188 Days and 20 Hours
Core Tip
Core Tip: We are now aware that maintaining a fine equilibrium between the host and its gut microbiota is a prerequisite to maintain host homeostasis and promote long-term health. Several host and microbial processes interact dynamically to respond to external stresses. Among these processes, host autophagy acts as a cytoprotective mechanism responsive to a wide range of stress conditions, including metabolic, immune, and microbial stimuli. Autophagy was initially described as a degradative process active upon nutrient starvation. However, this process fulfils a wide range of other functions that are essential to host homeostasis. We discuss herein reciprocal interactions of autophagy with the gut microbiota in health and disease conditions.
