Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2021; 27(48): 8262-8282
Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8262
Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8262
Issues of origin, morphology and clinical significance of tumor microvessels in gastric cancer
Marina A Senchukova, Department of Oncology, Orenburg State Medical University, Orenburg 460021, Russia
Author contributions: Senchukova MA solely contributed to this paper.
Conflict-of-interest statement: The author declares no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street, Orenburg 460021, Russia.
Received: March 25, 2021
Peer-review started: March 25, 2021
First decision: June 26, 2021
Revised: July 2, 2021
Accepted: December 7, 2021
Article in press: December 7, 2021
Published online: December 28, 2021
Processing time: 273 Days and 14.1 Hours
Peer-review started: March 25, 2021
First decision: June 26, 2021
Revised: July 2, 2021
Accepted: December 7, 2021
Article in press: December 7, 2021
Published online: December 28, 2021
Processing time: 273 Days and 14.1 Hours
Core Tip
Core Tip: In this review, data on the factors associated with the activation of angiogenesis in tumors, the mechanisms of tumor microvessel formation and the features of their morphology, methods for assessing the activity of angiogenesis in a tumor, and their role in the progression of gastric cancer (GC) are discussed. A new classification of tumor microvessels in GC based on their morphology and clinical significance is proposed. Considering the different types of tumor microvessels can have different sensitivities to antiangiogenic therapy, further study of their prognostic and predictive value is undoubtedly relevant.