Hu SJ, Zhao XK, Song X, Lei LL, Han WL, Xu RH, Wang R, Zhou FY, Wang L, Wang LD. Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma. World J Gastroenterol 2021; 27(4): 321-335 [PMID: 33584065 DOI: 10.3748/wjg.v27.i4.321]
Corresponding Author of This Article
Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2021; 27(4): 321-335 Published online Jan 28, 2021. doi: 10.3748/wjg.v27.i4.321
Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma
Shou-Jia Hu, Xue-Ke Zhao, Xin Song, Ling-Ling Lei, Wen-Li Han, Rui-Hua Xu, Ran Wang, Fu-You Zhou, Liang Wang, Li-Dong Wang
Shou-Jia Hu, Xue-Ke Zhao, Xin Song, Ling-Ling Lei, Wen-Li Han, Rui-Hua Xu, Ran Wang, Li-Dong Wang, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Fu-You Zhou, Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang 455000, Henan Province, China
Liang Wang, Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
Author contributions: Wang LD and Hu SJ designed and wrote the paper; Lei LL, Han WL, Xu RH, Wang R and Zhou FY performed data collection, interpretation and follow-up; Hu SJ, Zhao XK and Song X contributed to data analysis; Zhou FY, Wang L and Wang LD revised the manuscript; Wang L edited the manuscript for English language.
Supported byNational Natural Science Foundation of China, No. U1301227, No. 81872032 and No. U1804262; Doctoral Team Foundation of the First Affiliated Hospital of Zhengzhou University, No. 2016-BSTDJJ-03.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Zhengzhou University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no potential conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Received: October 13, 2020 Peer-review started: October 13, 2020 First decision: December 3, 2020 Revised: December 17, 2020 Accepted: December 24, 2020 Article in press: December 24, 2020 Published online: January 28, 2021 Processing time: 103 Days and 11.8 Hours
Core Tip
Core Tip: Reduced pulmonary function is considered a risk factor for cancer survival. The combination score of hemoglobin, albumin, lymphocytes and platelets (HALP) is a novel prognostic indicator to reflect nutritional and inflammatory status. We demonstrated that preoperative maximal voluntary ventilation (MVV), an important parameter of pulmonary function, and HALP score were independent prognostic factors for patients with esophageal squamous cell carcinoma. The combination of MVV and HALP score has a better prognostic value than tumor-node-metastasis alone. The combination of MVV and HALP score reflects the status of inflammation, nutrition and pulmonary function simultaneously and may partly compensate for the limitation of the tumor-node-metastasis staging system.
