Hu SJ, Zhao XK, Song X, Lei LL, Han WL, Xu RH, Wang R, Zhou FY, Wang L, Wang LD. Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma. World J Gastroenterol 2021; 27(4): 321-335 [PMID: 33584065 DOI: 10.3748/wjg.v27.i4.321]
Corresponding Author of This Article
Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2021; 27(4): 321-335 Published online Jan 28, 2021. doi: 10.3748/wjg.v27.i4.321
Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma
Shou-Jia Hu, Xue-Ke Zhao, Xin Song, Ling-Ling Lei, Wen-Li Han, Rui-Hua Xu, Ran Wang, Fu-You Zhou, Liang Wang, Li-Dong Wang
Shou-Jia Hu, Xue-Ke Zhao, Xin Song, Ling-Ling Lei, Wen-Li Han, Rui-Hua Xu, Ran Wang, Li-Dong Wang, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Fu-You Zhou, Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang 455000, Henan Province, China
Liang Wang, Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
Author contributions: Wang LD and Hu SJ designed and wrote the paper; Lei LL, Han WL, Xu RH, Wang R and Zhou FY performed data collection, interpretation and follow-up; Hu SJ, Zhao XK and Song X contributed to data analysis; Zhou FY, Wang L and Wang LD revised the manuscript; Wang L edited the manuscript for English language.
Supported byNational Natural Science Foundation of China, No. U1301227, No. 81872032 and No. U1804262; Doctoral Team Foundation of the First Affiliated Hospital of Zhengzhou University, No. 2016-BSTDJJ-03.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Zhengzhou University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no potential conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Dong Wang, MD, PhD, Professor, State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Received: October 13, 2020 Peer-review started: October 13, 2020 First decision: December 3, 2020 Revised: December 17, 2020 Accepted: December 24, 2020 Article in press: December 24, 2020 Published online: January 28, 2021 Processing time: 103 Days and 11.8 Hours
ARTICLE HIGHLIGHTS
Research background
Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative complications. Nutritional and systemic inflammation parameters are vital to cancer survival, and the combination of these parameters improves the prognostic value. The hemoglobin, albumin, lymphocytes and platelets (HALP) score is a novel prognostic indicator to reflect the nutritional and inflammation status.
Research motivation
The prognostic values of preoperative pulmonary function and the HALP score for survival in esophageal squamous cell carcinoma (ESCC) are unclear.
Research objectives
This study aimed to investigate the predictive values of preoperative pulmonary function and the HALP score for survival in ESCC patients.
Research methods
The predictive values of preoperative pulmonary function and the HALP score for long-term overall survival were performed in 834 ESCC patients who underwent radical esophagectomy.
Research results
Low maximal voluntary ventilation (MVV) and the HALP score were both independent risk factors for overall survival (all P < 0.001). The combination of MVV and HALP score (coMVV-HALP) improved the prediction performance for overall survival compared to tumor-node-metastasis, and low coMVV-HALP score was an independent risk factor for poor overall survival (P < 0.001).
Research conclusions
MVV, HALP score and their combination are simple and promising clinical markers to predict overall survival of ESCC patients.
Research perspectives
MVV and HALP score, alone or in combination, are simple and promising clinical predictors. Once validated in large cohorts, these clinical factors should be taken into account when assessing the prognosis of ESCC patients.
