Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2021; 27(39): 6673-6688
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6673
Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma
Tadeusz Sebzda, Jan Gnus, Barbara Dziadkowiec, Miroslaw Latka, Jakub Gburek
Tadeusz Sebzda, Barbara Dziadkowiec, Department of Pathophysiology, Wroclaw Medical University, Wroclaw 50-368, Poland
Jan Gnus, Department of Physiotherapy, Wroclaw Medical University, Wroclaw 50-355, Poland
Miroslaw Latka, Department of Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw 50-370, Poland
Jakub Gburek, Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw 50-556, Poland
Author contributions: Sebzda T, Gnus J and Gburek J performed the clinical studies; Sebzda T and Gburek J wrote the initial manuscript; All authors contributed to data analysis and the manuscript revisions.
Institutional review board statement: The study protocol was approved by the Ethics Committee of Wroclaw Medical University (KB 185/2013).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Barbara Dziadkowiec, MD, Doctor, Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, Wroclaw 50-368, Poland. dziadkowiecbarbara@gmail.com
Received: April 7, 2021
Peer-review started: April 7, 2021
First decision: May 27, 2021
Revised: July 7, 2021
Accepted: September 2, 2021
Article in press: September 2, 2021
Published online: October 21, 2021
Processing time: 195 Days and 15.7 Hours
Core Tip

Core Tip: We searched for biomarkers applicable to the early detection of colorectal adenocarcinoma. Five parameters were determined in sera of patients and healthy individuals: Cathepsin B activity, total sialic acids concentration, lipid-associated sialic acids concentration, elastase concentration, and alpha 1 antitrypsin activity. We performed receiver operating characteristic analysis for single and multiple parameters. While the sensitivity and specificity were not very high for single parameters, the combined analysis of cathepsin B, alpha 1 antitrypsin, and total sialic acids concentration yielded 88% sensitivity and 100% specificity. We believe that this set of markers can be useful in clinical practice.