Sebzda T, Gnus J, Dziadkowiec B, Latka M, Gburek J. Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma. World J Gastroenterol 2021; 27(39): 6673-6688 [PMID: 34754160 DOI: 10.3748/wjg.v27.i39.6673]
Corresponding Author of This Article
Barbara Dziadkowiec, MD, Doctor, Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, Wroclaw 50-368, Poland. dziadkowiecbarbara@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 21, 2021; 27(39): 6673-6688 Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6673
Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma
Tadeusz Sebzda, Jan Gnus, Barbara Dziadkowiec, Miroslaw Latka, Jakub Gburek
Tadeusz Sebzda, Barbara Dziadkowiec, Department of Pathophysiology, Wroclaw Medical University, Wroclaw 50-368, Poland
Jan Gnus, Department of Physiotherapy, Wroclaw Medical University, Wroclaw 50-355, Poland
Miroslaw Latka, Department of Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw 50-370, Poland
Jakub Gburek, Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw 50-556, Poland
Author contributions: Sebzda T, Gnus J and Gburek J performed the clinical studies; Sebzda T and Gburek J wrote the initial manuscript; All authors contributed to data analysis and the manuscript revisions.
Institutional review board statement: The study protocol was approved by the Ethics Committee of Wroclaw Medical University (KB 185/2013).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Barbara Dziadkowiec, MD, Doctor, Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, Wroclaw 50-368, Poland. dziadkowiecbarbara@gmail.com
Received: April 7, 2021 Peer-review started: April 7, 2021 First decision: May 27, 2021 Revised: July 7, 2021 Accepted: September 2, 2021 Article in press: September 2, 2021 Published online: October 21, 2021 Processing time: 195 Days and 15.7 Hours
ARTICLE HIGHLIGHTS
Research background
Recognition of the mechanisms involved in neoplastic cell spreading is indispensable for the early diagnosis and detection of colorectal cancer.
Research motivation
Colorectal cancer is the third most common type of cancer, making up about 10% of all cases. In 2018, there were 1.09 million new cases and 551000 deaths from the disease. Consequently, early diagnosis of colorectal cancer remains a significant medical and economic problem.
Research objectives
Using several biomarkers involved in cancer progression, we have tried to identify a panel that could be used for effective early diagnosis.
Research methods
Before surgery, we analyzed the blood serum of 185 patients with colorectal cancer and determined: Cathepsin B (CB), leukocytic elastase (LE), total sialic acid (TSA), lipid-bound sialic acid (LASA), and antitrypsin activity (ATA).
Research results
The receiver operating characteristic analysis revealed the potential diagnostic value of CB, TSA, and ATA. The sensitivity and specificity for the three-parameter panel CB-TSA-ATA were equal to 88.2% and 100%, respectively.
Research conclusions
The increased value of CB, TSA, and ATA parameters are associated with tumor biology, invasion, and metastasis of colorectal cancer.
Research perspectives
The presented evidence suggests the potential diagnostic and prognostic value of the CB-TSA-ATA biochemical marker panel.
