Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2021; 27(37): 6322-6331
Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6322
Pancreatic paraganglioma diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature
Gandhi Lanke, John M Stewart, Jeffrey H Lee
Gandhi Lanke, Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Lubbock, TX 79407, United States
John M Stewart, Pathology-lab Medicine Division, MD Anderson Cancer Center, Houston, TX 77030, United States
Jeffrey H Lee, Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, TX 77030, United States
Author contributions: Lanke G composed and drafted the paper; Stewart JM provided path images, revised, and edited the draft; Lee JH conceptualized, designed, revised, and edited the draft.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors have any potential conflicts (financial, professional, or personal) that are relevant to the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jeffrey H Lee, AGAF, FACG, FASGE, MD, Director, Professor, Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1466, Houston, TX 77030, United States. jefflee@mdanderson.org
Received: April 6, 2021
Peer-review started: April 6, 2021
First decision: June 17, 2021
Revised: June 28, 2021
Accepted: September 3, 2021
Article in press: September 3, 2021
Published online: October 7, 2021
Core Tip

Core Tip: The morphologic overlap between pancreatic paraganglioma and neuroendocrine tumor is significant. An accurate diagnosis by endoscopic ultrasound-guided fine needle aspiration requires firstly that the possibility of paraganglioma is considered and secondly that a cell block is available for immunohistochemical stains. A patient-centered approach supported by a multidisciplinary team of radiologists, advanced endoscopists, endocrinologists, pathologists, oncologists, and surgeons is paramount in the management of pancreatic paraganglioma.