Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2021; 27(37): 6277-6289
Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6277
Recently acquired hepatitis C virus infection among people living with human immunodeficiency virus at a university hospital in Taiwan
Miao-Hui Huang, Hsin-Yun Sun, Shu-Yuan Ho, Sui-Yuan Chang, Szu-Min Hsieh, Wang-Huei Sheng, Yu-Chung Chuang, Yu-Shan Huang, Li-Hsin Su, Wen-Chun Liu, Yi-Ching Su, Chien-Ching Hung
Miao-Hui Huang, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien 970410, Taiwan
Hsin-Yun Sun, Szu-Min Hsieh, Wang-Huei Sheng, Yu-Chung Chuang, Yu-Shan Huang, Li-Hsin Su, Wen-Chun Liu, Yi-Ching Su, Chien-Ching Hung, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100008, Taiwan
Shu-Yuan Ho, Sui-Yuan Chang, Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100008, Taiwan
Sui-Yuan Chang, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100233, Taiwan
Chien-Ching Hung, Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei 100233, Taiwan
Chien-Ching Hung, Department of Medical Research, China Medical University Hospital and China Medical University, Taichung 404394, Taiwan
Author contributions: Huang MH designed and performed the research; Sun HY and Hung CC designed the research and supervised the report; Ho SY and Chang SY provided laboratory support; Hung CC, Sun HY, Hsieh SM, Sheng WH, Chuang YC, Huang YS, Su LH, Liu WC, and Su YC were involved in the collection and assembly of clinical data; Huang MH and Hung CC participated in the data analysis and drafted the report; All authors reviewed and approved the final version of the report.
Supported by National Taiwan University Hospital, Taipei, Taiwan, No. NTUH106-003347 (to Sun HY).
Institutional review board statement: This retrospective study was approved by the Research Ethics Committee of National Taiwan University Hospital (registration number: 201605103RINC and 201605128RINC).
Informed consent statement: Written informed consents were obtained from all included participants prior to study inclusion.
Conflict-of-interest statement: The authors have no competing interest to disclose.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chien-Ching Hung, MD, PhD, Professor, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei 100008, Taiwan. hcc0401@ntu.edu.tw
Received: April 5, 2021
Peer-review started: April 5, 2021
First decision: July 3, 2021
Revised: July 13, 2021
Accepted: September 2, 2021
Article in press: September 2, 2021
Published online: October 7, 2021
Processing time: 177 Days and 6.5 Hours
Core Tip

Core Tip: We examined the hepatitis C virus (HCV) care cascade among people living with human immunodeficiency virus who acquired incident HCV infections at a university hospital in Taiwan between 2011 and 2018. We observed high rates of linkage to HCV care and retention in care in both interferon (IFN, 2011 to 2016) and direct-acting antiviral (DAA, 2017 to 2018) eras. The rate of referral to treatment assessment had increased from the IFN era to the DAA era. Moreover, the duration of HCV viremia was markedly shortened because of early diagnosis and linkage to effective treatment in the DAA era compared to that in the IFN era.