Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2021; 27(37): 6262-6276
Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6262
Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families
Ai-Ru Hsieh, Cathy S J Fann, Hung-Chun Lin, Jennifer Tai, Sen-Yung Hsieh, Dar-In Tai
Ai-Ru Hsieh, Department of Statistics, Tamkang University, New Taipei City 25137, Taiwan
Cathy S J Fann, Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 11529, Taiwan
Hung-Chun Lin, Jennifer Tai, Sen-Yung Hsieh, Dar-In Tai, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan 33305, Taiwan
Author contributions: Tai DI is the guarantor and designed the study; Hsieh AR and Fann CSJ participated in the statistical analysis and data interpretation; Lin HC, Tai J, Hsieh SY and Tai DI participated in the data acquisition; Fann CSJ revised the manuscript critically for important intellectual content.
Supported by Chang Gung Memorial Hospital, No. CMRPG3C0701; and National Science Council, No. NSC101-2314-B-182A-025-MY3 and No. MOST 107-2314-B-039-059.
Institutional review board statement: The study was approved by the institutional review board of Chang Gung Memorial Hospital, Taiwan (IRB 104-2596).
Informed consent statement: Written informed consent was obtained from all participants before the study. All experiments and data comparisons were carried out in compliance with relevant laws and guidelines, and in accord with the ethical standards of the Declaration of Helsinki.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dar-In Tai, MD, PhD, Professor, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan. tai48978@cgmh.org.tw
Received: April 8, 2021
Peer-review started: April 8, 2021
First decision: June 26, 2021
Revised: July 6, 2021
Accepted: September 1, 2021
Article in press: September 1, 2021
Published online: October 7, 2021
Processing time: 174 Days and 0.1 Hours
Core Tip

Core Tip: Hepatitis B virus (HBV)-related single nucleotide polymorphisms (SNPs) have been identified in East Asians. We evaluated five SNPs and nongenetic factors associated with HBV infection in a hepatocellular carcinoma family cohort. The factors were correlated with hepatitis B surface antigen (HBsAg) in the first-stage and with HBV viral load in the second-stage. The SNPs, sex, generation, and index case HBsAg contributed to persistent HBV infection. Neonatal tolerance and SNPs in the HLA loci were both independently associated with persistent HBV infection. A prolonged HBV replication phase in parents could be the main mechanism of persistent HBV infection in children in East Asia.