Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2021; 27(34): 5737-5752
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5737
MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan
Chia-Cheng Lee, Yu-Cheng Kuo, Je-Ming Hu, Pi-Kai Chang, Chien-An Sun, Tsan Yang, Chuan-Wang Li, Chao-Yang Chen, Fu-Huang Lin, Chih-Hsiung Hsu, Yu-Ching Chou
Chia-Cheng Lee, Je-Ming Hu, Pi-Kai Chang, Chao-Yang Chen, Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Chia-Cheng Lee, Medical Informatics Office, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Yu-Cheng Kuo, Fu-Huang Lin, Chih-Hsiung Hsu, Yu-Ching Chou, School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
Chien-An Sun, Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan
Chien-An Sun, Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan
Tsan Yang, Department of Health Business Administration, Meiho University, Pingtung 91202, Taiwan
Chuan-Wang Li, Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan
Chuan-Wang Li, Institute of Preventive Medicine, National Defense Medical Center, New Taipei City 237, Taiwan
Author contributions: Hsu CH and Chou YC contributed equally to this work; Lee CC, Hsu CH and Chou YC designed the research; Sun CA, Yang T and Li CW performed the research; Hu JM, Chang PK and Chen CY collected the data; Lee CC, Kuo YC, Hsu CH, Lin FH and Chou YC analyzed the data; Lee CC, Hsu CH and Chou YC wrote the paper.
Supported by the grant from the Ministry of National Defense-Medical Affairs Bureau, Taiwan, No. MND-MAB-110-109 and No. MND-MAB-D-111059.
Institutional review board statement: This study was approved by the TSGH Institutional Review Board (TSGHIRB approval number: 098-05-292 and 2-105-05-129).
Informed consent statement: Written informed consent was obtained from all patients before enrollment into the study to evaluate their prognosis.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Ching Chou, PhD, Professor, School of Public Health, National Defense Medical Center, No. 161 Sec. 6, Minquan E. Road, Neihu District, Taipei 114, Taiwan. trishow@mail.ndmctsgh.edu.tw
Received: April 15, 2021
Peer-review started: April 15, 2021
First decision: June 23, 2021
Revised: June 30, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: September 14, 2021
Core Tip

Core Tip: In this retrospective cohort study, we found that MTNR1B single-nucleotide polymorphism were associated with a significantly increased risk of colorectal cancer (CRC) 5-year overall survival. A strong cumulative effect of the four polymorphisms on CRC prognosis was observed. This study indicated the novel genetic biomarkers, MTNR1B, combined with CDKN2A and MGMT gene methylation statuses, maybe a predictive tool for CRC prognosis.