Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2021; 27(20): 2657-2663
Published online May 28, 2021. doi: 10.3748/wjg.v27.i20.2657
Published online May 28, 2021. doi: 10.3748/wjg.v27.i20.2657
Cyclophosphamide-associated enteritis presenting with severe protein-losing enteropathy in granulomatosis with polyangiitis: A case report
Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii, Tomonori Ishii, Hideo Harigae, Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai 9808574, Japan
Author contributions: Sato H and Shirai T performed the literature review, and wrote the manuscript; Shirai T, Fujii H, Ishii T, and Harigae H were involved in the clinical management.
Supported by Funding for Scientific Research (Funding for Academic Research) , No. 18K16136 .
Informed consent statement: Written informed consent for the publication of this case report was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tsuyoshi Shirai, MD, PhD, Assistant Professor, Doctor, Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 9808574, Japan. tsuyoshirajp@med.tohoku.ac.jp
Received: January 25, 2021
Peer-review started: January 25, 2021
First decision: February 27, 2021
Revised: March 9, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: May 28, 2021
Peer-review started: January 25, 2021
First decision: February 27, 2021
Revised: March 9, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: May 28, 2021
Core Tip
Core Tip: Cyclophosphamide-associated enteritis is rare, but a fatal complication of the treatment for the vasculitides. This is the first successful report of the treatment for the severe cyclophosphamide-associated enteritis, and indicates the importance of immediate discontinuation of cyclophosphamide and intensive supportive therapy.