Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2020; 26(41): 6414-6430
Published online Nov 7, 2020. doi: 10.3748/wjg.v26.i41.6414
Signature based on molecular subtypes of deoxyribonucleic acid methylation predicts overall survival in gastric cancer
Jin Bian, Jun-Yu Long, Xu Yang, Xiao-Bo Yang, Yi-Yao Xu, Xin Lu, Xin-Ting Sang, Hai-Tao Zhao
Jin Bian, Jun-Yu Long, Xu Yang, Xiao-Bo Yang, Yi-Yao Xu, Xin Lu, Xin-Ting Sang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Bian J and Long JY contributed equally to this work; Bian J and Long JY collected the data, performed the analysis, and wrote the manuscript; Yang X participated in preparing the figures and tables; Yang XB, Xu YY, and Lu X helped to collect the literature and participated in discussions; Sang XT and Zhao HT designed and contributed equally to the study; all authors read and approved the final manuscript.
Supported by the International Science and Technology Cooperation Projects, No. 2016YFE0107100; Capital Special Research Project for Health Development, No. 2014-2-4012; Beijing Natural Science Foundation, No. L172055 and No. 7192158; National Ten-thousand Talent Program, the Fundamental Research Funds for the Central Universities, No. 3332018032; and CAMS Innovation Fund for Medical Science (CIFMS), No. 2017-I2M-4-003 and No. 2018-I2M-3-001.
Institutional review board statement: All data were downloaded from the Cancer Genome Atlas and the University of California Santa Cruz (UCSC) Cancer Browser, which are open to the public under certain restrictions, therefore no ethical approval was required.
Informed consent statement: The data used in the current study are obtained from The Cancer Genome Atlas database (TCGA) and the University of California Santa Cruz (UCSC) Cancer Browser, which are open to the public under some guidelines. Therefore, it is confirmed that all written informed consent was achieved.
Conflict-of-interest statement: We declare that the authors have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Tao Zhao, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhaoht@pumch.cn
Received: July 20, 2020
Peer-review started: July 20, 2020
First decision: August 8, 2020
Revised: August 17, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: November 7, 2020
Processing time: 108 Days and 20.4 Hours
Core Tip

Core Tip: To address the epigenetic heterogeneity of gastric cancer, three subgroups based on deoxyribonucleic acid (DNA) methylation were identified and each subtype was associated with distinct survival and clinical features. A signature based on molecular subtypes of DNA methylation was built to predict the survival of gastric cancer patients, and showed good performance. This work may improve our understanding of the epigenetic landscape of gastric cancer and facilitate precision medicine for these patients.