Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2020; 26(39): 6057-6073
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.6057
Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease
Yin-Chen Wu, Ze-Bin Xiao, Xue-Hua Lin, Xian-Ying Zheng, Dai-Rong Cao, Zhong-Shuai Zhang
Yin-Chen Wu, Xue-Hua Lin, Xian-Ying Zheng, Dai-Rong Cao, Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Ze-Bin Xiao, Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, United States
Zhong-Shuai Zhang, Department of Diagnosis Imaging, Siemens Healthcare Ltd, Shanghai 201318, China
Author contributions: Wu YC made substantial contributions to the conception and design of the study, performing the study, acquisition of data and drafting the manuscript; Xiao ZB carried out the statistical analyses and image post-processing; Lin XH performed the scanning sequences; Zhang ZS was responsible for sequence optimization; Cao DR participated in the design and helped in drafting the manuscript; Zheng XY conceived the study idea, participated in its design, and helped in drafting the manuscript; all authors have read and approved the final manuscript.
Supported by Medical Innovation Program of Fujian Province, No. 2018-CX-30; and Startup Fund for Scientific Research of Fujian Medical University, No. 2018QH1054.
Institutional review board statement: The study was reviewed and approved by the Branch for Medical Research and Clinical Technology Application, Ethics Committee of First Affiliated Hospital of Fujian Medical University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Ying Zheng, MD, Professor, Department of Radiology, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou 350005, Fujian Province, China. fyzhengxianying@163.com
Received: June 19, 2020
Peer-review started: June 19, 2020
First decision: July 28, 2020
Revised: August 6, 2020
Accepted: September 12, 2020
Article in press: September 12, 2020
Published online: October 21, 2020
Processing time: 124 Days and 12.4 Hours
Core Tip

Core Tip: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) can reflect quantitative changes in perfusion and permeability information on the microcirculation of bowel walls due to variable degrees of inflammation. This study investigated the performances of DCE-MRI and DWI for assessing the activity of Crohn’s disease (CD). The results showed that DCE-MRI and DWI parameters were correlated with CD inflammation indices and were valuable in noninvasively staging CD activity. Furthermore, the diagnostic performance of the transfer constant (Ktrans), wash-out constant (Kep), extravascular extracellular volume fraction (Ve) and ADC was better than the Magnetic Resonance Index of Activity, which can assist clinical diagnosis and monitoring.