Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2020; 26(39): 5970-5982
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.5970
Polyethylene glycol 35 ameliorates pancreatic inflammatory response in cerulein-induced acute pancreatitis in rats
Ana Ferrero-Andrés, Arnau Panisello-Roselló, Joan Roselló-Catafau, Emma Folch-Puy
Ana Ferrero-Andrés, Arnau Panisello-Roselló, Experimental Pathology Department, Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicas, Barcelona 08036, Catalonia, Spain
Joan Roselló-Catafau, Emma Folch-Puy, Experimental Pathology Department, Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicas, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona 08036, Catalonia, Spain
Author contributions: Roselló-Catafau J and Folch-Puy E designed the study; Folch-Puy E coordinated the study; Ferrero-Andrés A and Panisello-Roselló A performed the experiments and acquired and analysed data; Ferrero-Andrés A and Folch-Puy E interpreted the data; Ferrero-Andrés A and Folch-Puy E wrote the original draft of the manuscript; Ferrero-Andrés A, Panisello-Roselló A, Roselló-Catafau J and Folch-Puy E reviewed and edited the manuscript; all authors approved the final version of the article.
Supported by the grant from Ministerio de Ciencia e Innovación, No. PID2019-104130RB-I00.
Institutional animal care and use committee statement: All experimental animals’ procedures were conducted in accordance with European Union regulatory standards for animal experimentation (Directive 2010/63/EU on the protection of animals used for scientific purposes). The Ethical Committee for Animal Experimentation (CEEA, ethic approval number: 211/18, University of Barcelona, 11/04/2018) approved the animal experiments.
Conflict-of-interest statement: The authors have disclosed that they do not have any conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Emma Folch-Puy, PhD, Senior Scientist, Experimental Pathology Department, Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicas, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, C/Roselló 161, Barcelona 08036, Catalonia, Spain. emma.folch@iibb.csic.es
Received: July 21, 2020
Peer-review started: July 21, 2020
First decision: August 8, 2020
Revised: August 12, 2020
Accepted: September 12, 2020
Article in press: September 12, 2020
Published online: October 21, 2020
Core Tip

Core Tip: Acute pancreatitis (AP) is a sudden inflammatory condition of the pancreas with variable involvement of peri-pancreatic tissues and/or remote organ systems. This disease is a major clinical challenge for which no specific pharmacological therapy currently exists. The manuscript describes the protective role of 35-kDa molecular weight polyethylene glycol (PEG35) on cerulein-induced AP. PEG35 treatment was able to lessen the inflammatory process in the pancreas and associated cell death in cerulein-induced AP and in vitro models of pancreatic damage.