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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2020; 26(39): 5919-5943
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.5919
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.5919
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease
Alejandro Campos-Murguía, Astrid Ruiz-Margáin, José A González-Regueiro, Ricardo U Macías-Rodríguez, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
Author contributions: Macías-Rodríguez RU contributed to conception and design of the review; Campos-Murguía A, Ruiz-Margáin A, González-Regueiro JA and Macías-Rodríguez RU contributed with literature review, writing and analysis of data; Campos-Murguía A, Ruiz-Margáin A and Macías-Rodríguez RU contributed with drafting, critical revision, supervision and editing of the content of the manuscript; Campos-Murguía A, Ruiz-Margáin A, González-Regueiro JA and Macías-Rodríguez RU contributed to writing the final version of the manuscript.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ricardo U Macías-Rodríguez, MD, MSc, PhD, Assistant Professor, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Liver Fibrosis and Nutrition lab (LFN-Lab). MICTLÁN Network: mechanisms of liver injury, cell death and translational nutrition in liver diseases-research network. Vasco de Quiroga 15, Col. Belisario Domínguez Sección XVI, Mexico City 14080, Mexico. ricardomacro@yahoo.com.mx
Received: May 15, 2020
Peer-review started: May 15, 2020
First decision: May 21, 2020
Revised: May 24, 2020
Accepted: September 22, 2020
Article in press: September 22, 2020
Published online: October 21, 2020
Processing time: 158 Days and 23.5 Hours
Peer-review started: May 15, 2020
First decision: May 21, 2020
Revised: May 24, 2020
Accepted: September 22, 2020
Article in press: September 22, 2020
Published online: October 21, 2020
Processing time: 158 Days and 23.5 Hours
Core Tip
Core Tip: The most important liver-related factor associated with adverse clinical outcomes and mortality in patients with non-alcoholic fatty liver disease (NAFLD) is the presence and progression of fibrosis; its progression depends upon genetic, clinical, and biochemical risk factors, that must be assessed in order to identify patients at risk. To be able to accurately identify fibrosis we must take into account the diagnostic ability of each method and its possible variations according to the local prevalence and the selected cutoffs. This review summarizes the available data on assessment and management of NAFLD with a comprehensive analysis of the current diagnostic methods.