Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2020; 26(36): 5450-5462
Published online Sep 28, 2020. doi: 10.3748/wjg.v26.i36.5450
Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer
Yuichiro Ozeki, Kingo Hirasawa, Ryosuke Kobayashi, Chiko Sato, Yoko Tateishi, Atsushi Sawada, Ryosuke Ikeda, Masafumi Nishio, Takehide Fukuchi, Makomo Makazu, Masataka Taguri, Shin Maeda
Yuichiro Ozeki, Kingo Hirasawa, Ryosuke Kobayashi, Chiko Sato, Atsushi Sawada, Ryosuke Ikeda, Masafumi Nishio, Takehide Fukuchi, Makomo Makazu, Division of Endoscopy, Yokohama City University Medical Center, Yokohama 232-0024, Japan
Yoko Tateishi, Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Masataka Taguri, Department of Data Science, Yokohama City University School of Data Science, Yokohama 236-0004, Japan
Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Author contributions: Ozeki Y and Hirasawa K equally contributed to conception, design, and writing this article; Ozeki Y, Hirasawa K, Kobayashi R, Sato C, and Tateishi Y reviewed all the histopathological slides and endoscopic images studied in this article; Ozeki Y, Hirasawa K, Kobayashi R, Sato C, Sawada A, Ikeda R, Nishio M, Fukuchi T, and Makazu M performed endoscopic treatment for patients studied in this article; Taguri M provided statistical assistance required in this study; Hirasawa K and Maeda S supervised the draft of this article; Each co-author read and approved of the final version of this article.
Institutional review board statement: The study protocol was reviewed and approved by the Ethics Committee of Yokohama City University Medical Center Hospital (Approval number: D1602024).
Informed consent statement: Patients were not required to provide informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kingo Hirasawa, MD, PhD, Associate Professor, Division of Endoscopy, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama 232-0024, Japan. kingo-h@urahp.yokohama-cu.ac.jp
Received: May 18, 2020
Peer-review started: May 18, 2020
First decision: July 29, 2020
Revised: August 7, 2020
Accepted: September 8, 2020
Article in press: September 8, 2020
Published online: September 28, 2020
Processing time: 128 Days and 22.1 Hours
Core Tip

Core Tip: Accurate pretreatment diagnosis of the undifferentiated-type (UDT) component was hardly achieved even when pretreatment biopsy and diagnostic endoscopy were combined. Histopathological UDT predominance was the single significant factor associated with the presence of the endoscopic UDT component finding. The possibility of UDT predominance should be suspected when a lesion shows an endoscopic finding of the UDT component. Endoscopic resection plays a significant role in both the diagnosis and treatment of mixed-histological-type early gastric cancers.