Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2020; 26(31): 4694-4702
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4694
Clinical characteristics and risk factors for liver injury in COVID-19 patients in Wuhan
Hu Zhang, Yu-Sheng Liao, Jing Gong, Jing Liu, Heng Zhang
Hu Zhang, Yu-Sheng Liao, Jing Gong, Jing Liu, Heng Zhang, Department of Gastroenterology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Author contributions: Zhang H designed this study and critically revised the manuscript; Zhang H, Gong J, and Liu J were responsible for data acquisition and extraction; Zhang H and Zhang H drafted the manuscript, analyzed the data, and interpreted the results; Gong J and Liao YS were involved in editing the manuscript; all authors read and approved the final manuscript to be published.
Supported by the Health and Family Planning Commission of Wuhan, No. WX18Y04.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Central Hospital of Wuhan.
Informed consent statement: The Ethics Committee of the Central Hospital of Wuhan waived the informed consent statement.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Heng Zhang, MA, MD, Chief Doctor, Department of Gastroenterology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang’an District, Wuhan 430014, Hubei Province, China. 497697662@qq.com
Received: May 9, 2020
Peer-review started: May 9, 2020
First decision: June 13, 2020
Revised: June 20, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 21, 2020
Processing time: 104 Days and 2.7 Hours
Core Tip

Core tip: Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic. This study analyzed the clinical characteristics and risk factors for liver injury in COVID-19 patients in Wuhan. The early stage of COVID-19 may be associated with mildly elevated aminotransferase levels. Male sex and high D-dimer level and neutrophil percentage may be important predictors of liver injury in patients with COVID-19.