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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2020; 26(31): 4656-4668
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4656
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4656
Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors
Huai-Liang Li, Yi-Lin Hu, Ying Feng, Peng Li, Qin-Sheng Mao, Wan-Jiang Xue, Department of Gastrointestinal Surgery, Nantong University Affiliated Hospital, Nantong 226001, Jiangsu Province, China
Lin-Hua Wang, Department of Intensive Care Unit, Nantong University Affiliated Hospital, Nantong 226001, Jiangsu Province, China
Xiao-Hong Li, Department of Surgical Comprehensive Laboratory, Nantong University Affiliated Hospital, Nantong 226001, Jiangsu Province, China
Yi-Fei Liu, Department of Pathology, Nantong University Affiliated Hospital, Nantong 226001, Jiangsu Province, China
Author contributions: Li HL and Wang LH contributed equally to this work; Li HL wrote the paper; Wang LH performed the research; Hu YL contributed new reagents or analytic tools; Feng Y and Liu YF analyzed the data; Mao QS and Xue WJ edited the paper and provided primary revised opinion; Xue WJ designed the research.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Nantong University Affiliated Hospital.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wan-Jiang Xue, FAASLD, BSc, MD, PhD, Chief Doctor, Professor, Department of Gastrointestinal Surgery, Nantong University Affiliated Hospital, No. 20 Xisi Street, Nantong 226001, Jiangsu Province, China. xuewanjiang@ntu.edu.cn
Received: March 4, 2020
Peer-review started: March 4, 2020
First decision: April 25, 2020
Revised: June 7, 2020
Accepted: July 18, 2020
Article in press: July 18, 2020
Published online: August 21, 2020
Peer-review started: March 4, 2020
First decision: April 25, 2020
Revised: June 7, 2020
Accepted: July 18, 2020
Article in press: July 18, 2020
Published online: August 21, 2020
Core Tip
Core tip: Although the application of c-kit inhibitors prolonged survival for advanced gastrointestinal stromal tumor (GIST) patients, the prognosis was not optimistic. Because of the role in tumor immunity, chemokine receptors have been identified as independent prognostic factors in various cancers but have not been investigated in GISTs. We evaluated CC chemokine receptor type 8 expression in GISTs by immunohistochemistry and analyzed its relationships with clinicopathological features and prognosis. We also investigated its role in tumor immunity. These confirmed that CC chemokine receptor type 8 can be used as an independent prognostic factor for GISTs and even as a potential therapeutic target.