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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2020; 26(31): 4624-4638
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4624
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4624
Impact of interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer patients
Shi-Wen Mei, Zheng Liu, Fang-Ze Wei, Jia-Nan Chen, Zhi-Jie Wang, Hai-Yu Shen, Juan Li, Fu-Qiang Zhao, Wei Pei, Zheng Wang, Xi-Shan Wang, Qian Liu, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Mei SW, Chen JN, and Wang ZJ designed the research; Wei FZ, Shen HY, Li J, and Zhao FQ collected the data; Pei W, Wang Z, Liu Z, and Wei FZ analyzed the data; Mei SW drafted the manuscript; Liu Q and Wang XS revised the paper.
Supported by the National Key Research and Development Plan "Research on Prevention and Control of Major Chronic Non-Communicable Diseases" , No. 2019YFC1315705 ; and the Medicine and Health Technology Innovation Project of Chinese Academy of Medical Sciences , No. 2017-12M-1-006 .
Institutional review board statement: Our investigation received approval from the ethics committee of the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest in regard to this research.
Data sharing statement: No additional data are available.
STROBE statement: The authors have carefully read the STROBE statement checklist of items and prepared the manuscript based on the requirements of the STROBE statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qian Liu, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. fcwpumch@163.com
Received: May 26, 2020
Peer-review started: May 26, 2020
First decision: June 4, 2020
Revised: June 7, 2020
Accepted: August 1, 2020
Article in press: August 1, 2020
Published online: August 21, 2020
Processing time: 86 Days and 21.7 Hours
Peer-review started: May 26, 2020
First decision: June 4, 2020
Revised: June 7, 2020
Accepted: August 1, 2020
Article in press: August 1, 2020
Published online: August 21, 2020
Processing time: 86 Days and 21.7 Hours
Core Tip
Core tip: The time interval between neoadjuvant therapy and surgery is an underlying debate. This study mainly analyzed the effect of prolonging the time interval to surgery after neoadjuvant therapy on pathologic response and disease-free survival. Our study concluded that time interval > 9 wk will result in better prognosis and oncologic outcomes than time interval ≤ 9 wk. In practice, we should prolong the time interval to obtain favorable outcomes in advanced rectal cancer after neoadjuvant therapy.