Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2020; 26(12): 1298-1316
Published online Mar 28, 2020. doi: 10.3748/wjg.v26.i12.1298
Exploring prognostic potential of long noncoding RNAs in colorectal cancer based on a competing endogenous RNA network
Zhi-Dong Yang, Hui Kang
Zhi-Dong Yang, Hui Kang, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Yang ZD was responsible for drafting the manuscript and data analysis; Kang H was responsible for the revision of the manuscript; all authors provided final approval for the version to be submitted.
Institutional review board statement: The present study was approved by The First Affiliated Hospital of China Medical University Ethics Committee. All patients provided written informed consent for participation in the study. Consent for the publication of the clinical and pathological data was obtained from all patients involved in this study.
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hui Kang, PhD, Professor, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Shenyang 110001, Liaoning Province, China. kanghui65@sina.com
Received: December 1, 2019
Peer-review started: December 1, 2019
First decision: December 23, 2019
Revised: January 8, 2020
Accepted: March 9, 2020
Article in press: March 9, 2020
Published online: March 28, 2020
Processing time: 117 Days and 21.9 Hours
Core Tip

Core tip: Although there have been improvements in the treatment of colorectal cancer, a number of patients still lost the chance for survival because of a shortage of useful biomarkers. In this study, we systematically analyzed RNA transcriptome profile and constructed a prognostic-related competing endogenous RNA network by a comprehensive analysis, constructed a four-lncRNA model, and evaluated the predictive value of this model in the Gene Expression Omnibus and the Cancer Genome Atlas databases. Our understanding of the long noncoding RNA-related competing endogenous RNA regulatory mechanism could provide a potential diagnostic indicator for colorectal cancer patients.