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World J Gastroenterol. Mar 28, 2020; 26(12): 1273-1285
Published online Mar 28, 2020. doi: 10.3748/wjg.v26.i12.1273
Importance of genetic polymorphisms in liver transplantation outcomes
Tomislav Kelava, Petra Turcic, Antonio Markotic, Ana Ostojic, Dino Sisl, Anna Mrzljak
Tomislav Kelava, Dino Sisl, Laboratory for Molecular Immunology, Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb 10000, Croatia
Petra Turcic, Department of Pharmacology, Faculty of Pharmacy and Biochemistry of University of Zagreb, Zagreb 10000, Croatia
Antonio Markotic, Center for Clinical Pharmacology, University Clinical Hospital Mostar, Mostar 88000, Bosnia and Herzegovina
Ana Ostojic, Department of Medicine, Merkur University Hospital, Zagreb 10000, Croatia
Anna Mrzljak, Department of Medicine, Merkur University Hospital; School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Supported by the Croatian Science Foundation grant “The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis” , No. UIP-2017-05-1965.
Author contributions: Kelava T and Mrzljak A made contributions to the conception and design of the study, were involved in drafting and revising the manuscript critically; Turcic P, Markotic A, Ostojic A and Sisl D were involved in collecting data and drafting the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anna Mrzljak, MD, PhD, Associate Professor, Department of Medicine, Merkur University Hospital; School of Medicine, University of Zagreb, Zajceva 19, Zagreb 10000, Croatia. anna.mrzljak@mef.hr
Received: December 31, 2019
Peer-review started: December 31, 2019
First decision: February 19, 2020
Revised: March 1, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 28, 2020
Core Tip

Core tip: Better stratification of risk before transplantation and/or selection of appropriate donor are crucial to reduce post-transplant complications and improve outcomes. The contribution of genetic risk associated with single nucleotide polymorphisms for the most common complications along with the immunosuppression after liver transplantation is briefly summarized in this review.