Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2019; 25(8): 1012-1023
Published online Feb 28, 2019. doi: 10.3748/wjg.v25.i8.1012
Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer
Zhi-Fang Jia, Dong-Hui Cao, Yan-Hua Wu, Mei-Shan Jin, Yu-Chen Pan, Xue-Yuan Cao, Jing Jiang
Zhi-Fang Jia, Dong-Hui Cao, Yan-Hua Wu, Yu-Chen Pan, Jing Jiang, Division of Clinical Research, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Mei-Shan Jin, Division of Pathology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Xue-Yuan Cao, Department of Gastrointestinal Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiang J and Cao XY designed the research; Jia ZF, Cao DH, Wu YH, Pan YC, and Jin MS performed the research; Jia ZF and Jiang J analyzed the data; Jia ZF wrote the manuscript; Jiang J and Cao XY revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81703293, 81673145, and No. 81373084; the Research Program of the Education Department of Jilin Province, No. 2016487; the Scientific and Technological Development Program of Jilin Province, No. 20180414055GH.
Institutional review board statement: This study was reviewed and approved the Ethics Committee of the First Hospital of Jilin University (Changchun, China).
Informed consent statement: All the subjects gave written informed consent to participate in the study before enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The items that should be included in reports of observational studies were checked and the file of STROBE statement was uploaded.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jing Jiang, PhD, Professor, Statistician, Division of Clinical Research, the First Hospital of Jilin University, No. 71, Xinmin Street, Changchun 130021, Jilin Province, China. jiangjing19702000@jlu.edu.cn
Telephone: +86-431-81875408 Fax: +86-431-85654528
Received: December 4, 2018
Peer-review started: December 6, 2018
First decision: January 6, 2019
Revised: January 18, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 28, 2019
Processing time: 85 Days and 13.6 Hours
Core Tip

Core tip: This study included a relatively large number of gastric cancer patients and tumor-free controls and explored the relationship of ten lethal-7 (let-7)-related single nucleotide polymorphisms with gastric carcinogenesis and prognosis. The results showed that the LIN28A rs3811463 polymorphism of the let-7 target was associated with the development of gastric cancer and that the IL23R rs10889677 polymorphism was related to the overall survival of gastric cancer patients in a dose-dependent manner. This study adds evidence that polymorphisms represent a genetic factor that modifies the susceptibility to and prognosis of gastric cancer.