Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2019; 25(7): 837-847
Published online Feb 21, 2019. doi: 10.3748/wjg.v25.i7.837
Published online Feb 21, 2019. doi: 10.3748/wjg.v25.i7.837
Nutrient drink test: A promising new tool for irritable bowel syndrome diagnosis
Fermin Estremera-Arevalo, Department of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona 31008, Spain
Marta Barcelo, Department of Gastroenterolgy, Hospital Infanta Leonor, Madrid 28031, Spain
Blanca Serrano, Department of Digestive Diseases, Hospital Clinico San Carlos, Madrid 28040, Spain
Enrique Rey, Department of Digestive Diseases, Hospital Clinico San Carlos and Complutense University, Madrid 28040, Spain
Author contributions: Estremera-Arevalo F, Barcelo M, and Rey E designed the project; Estremera-Arevalo F and Serrano B performed the nutrient drink test; Estremera-Arevalo F drafted the manuscript and generated the database; Barcelo M, Serrano B, and Rey E reviewed the manuscript; Rey E performed the statistics.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Hospital Clinico San Carlos.
Informed consent statement: All participants gave informed consent after a careful explanation of the methods and objectives of this study.
Conflict-of-interest statement: None of the authors have conflicts of interest to be declared.
Data sharing statement: Clinical data record, statistical code, and dataset available from the corresponding author at festremera15@gmail.com.
STROBE statement: The guidelines of the STROBE Statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Fermin Estremera-Arevalo, MD, PhD, Doctor, Staff Physician, Gastroenterologist, Department of Gastroenterology, Complejo Hospitalario de Navarra, Calle Irunlarrea, 3, Pamplona 31008, Spain. festremera15@gmail.com
Telephone: +34-848-422222 Fax: +34-848-422303
Received: October 13, 2018
Peer-review started: October 14, 2018
First decision: November 14, 2018
Revised: January 11, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 21, 2019
Processing time: 134 Days and 1.2 Hours
Peer-review started: October 14, 2018
First decision: November 14, 2018
Revised: January 11, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 21, 2019
Processing time: 134 Days and 1.2 Hours
Core Tip
Core tip: There is no objective non-invasive test for diagnosis of irritable bowel syndrome. This study shows that measurement of early gastrointestinal symptoms provoked by ingestion of a caloric drink is a promising diagnostic tool for this syndrome. This test could allay patient and doctor uncertainty and reduce the use of costly and invasive diagnostic tests.