Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2019; 25(40): 6145-6157
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6145
Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study
Ravi Misra, Jimmy Limdi, Rachel Cooney, Samia Sakuma, Matthew Brookes, Edward Fogden, Sanjeev Pattni, Naveen Sharma, Tariq Iqbal, Pia Munkholm, Johan Burisch, Naila Arebi
Ravi Misra, Samia Sakuma, Naila Arebi, Gastroenterology, St. Mark’s Hospital and Academic Institute, London HA1 3UJ, United Kingdom
Jimmy Limdi, The Pennine Acute Hospitals NHS Trust, Institute of Inflammation and Repair, University of Manchester, Manchester BL9 7TD, United Kingdom
Rachel Cooney, Tariq Iqbal, Gastroenterology, University Hospitals Birmingham, Birmingham B12 2TH, United Kingdom
Matthew Brookes, Gastroenterology, Royal Wolverhampton NHS Trust, London WV10 0QP, United Kingdom
Edward Fogden, Gastroenterology, Sandwell and West Birmingham Hospitals, Birmingham B71 4HJ, United Kingdom
Sanjeev Pattni, Gastroenterology, University Leicester Hospitals, Leicester LE1 5WW, United Kingdom
Naveen Sharma, Gastroenterology, Heartlands Hospital, Birmingham B9 5SS, United Kingdom
Pia Munkholm, Johan Burisch, Department of Gastroenterology, North Zealand University Hospital, Frederikssund 3600, Denmark
Author contributions: Misra R and Arebi N designed the study; Misra R analysed the data; Sakuma S supervised the study centres; Misra R and Arebi N wrote the paper; all authors critically appraised the paper and recruited patients to the study.
Institutional review board statement: The study was approved by the London Northwest NHS Trust and National Research Ethics Service (REC number14/EM/1290).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ravi Misra, BSc, MRCP, Doctor, Consultant Gastroenterologist, Department of Gastroenterology, St. Mark’s Hospital and Academic Institute, Watford Rd, Harrow, London HA1 3UJ, United Kingdom. rm399@ic.ac.uk
Telephone: +44-208-8695328
Received: June 3, 2019
Peer-review started: June 3, 2019
First decision: July 21, 2019
Revised: August 1, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: October 28, 2019
Processing time: 147 Days and 13.2 Hours
Core Tip

Core tip: We performed a United Kingdom multicentre prospective cohort study to describe the incidence of inflammatory bowel disease and differences within ethnic groups. Seven urban centres with high ethnic background population recruited 339 cases over a 1 year period. Patients of Indian ethnicity were almost three times more likely to have UC than White Europeans. The impact of diet and environmental factors on this high risk population requires further study.