Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2017; 23(5): 800-809
Published online Feb 7, 2017. doi: 10.3748/wjg.v23.i5.800
Genomic variability of Helicobacter pylori isolates of gastric regions from two Colombian populations
Andrés Jenuer Matta, Alvaro Jairo Pazos, Javier Andrés Bustamante-Rengifo, Luis Eduardo Bravo
Andrés Jenuer Matta, Luis Eduardo Bravo, Javier Andrés Bustamante, Registro Poblacional de Cáncer de Cali, Department of Pathology, School of Medicine, Universidad del Valle, Cali 760043, Colombia
Alvaro Jairo Pazos, Department of Biology, Universidad de Nariño, Pasto 520002, Colombia
Author contributions: All the authors that were involved in the acquisition and interpretation of the results, read and approved the final manuscript; Matta AJ, Pazos AJ and Bustamante-Rengifo JA conducted the microbiological and molecular tests; Matta AJ and Bravo LE analyzed the data; Matta AJ, Pazos AJ, Bustamante-Rengifo JA and Bravo LE wrote, edited, and revised the manuscript.
Institutional review board statement: All procedures involving human participants were reviewed and approved by the Ethics Committee at Universidad del Valle, Cali, Colombia.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at andres.matta@correounivalle.edu.co Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Andres Jenuer Matta, MSc, PhD, Registro Poblacional de Cáncer de Cali, Department of Pathology, School of Medicine, Universidad del Valle, Street 4B No. 36-00, Building 116, Floor 4, Cali 760043, Colombia. andres.matta@correounivalle.edu.co
Telephone: +57-2-5185623 Fax: +57-2-3212100
Received: July 13, 2016
Peer-review started: July 17, 2016
First decision: August 19, 2016
Revised: September 5, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: February 7, 2017
Processing time: 193 Days and 2.5 Hours
Core Tip

Core tip: Multiple colonization of Helicobacter pylori (H. pylori) occurred more frequently in individuals living in the Colombian population with higher risk of gastric cancer (GC) (Túquerres). In the two populations contrasted in relation to the risk of developing GC. (Túquerres high risk and Tumaco low risk) H. pylori was identified with specific genetic characteristics for each region and with varying stages of genomic variability. The diversity of H. pylori dependent of the anatomic regions of the gastric mucosa, obstructs the eradication of the microorganism. Identifying the multiple colonization and evaluating the genetic diversity of H. pylori individuals may be sifted that require particular schemes of early treatment and prevention of the precursor lesions of GC.