Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2017; 23(37): 6911-6919
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6911
Rupture of small cystic pancreatic neuroendocrine tumor with many microtumors
Ryota Sagami, Hidefumi Nishikiori, Shoichiro Ikuyama, Kazunari Murakami
Ryota Sagami, Hidefumi Nishikiori, Department of Gastroenterology, Oita San-ai Medical Center, Oita 8701151, Japan
Shoichiro Ikuyama, Department of Internal Medicine and Clinical Investigation, Oita San-ai Medical Center, Oita 8701151, Japan
Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yuhu 8795503, Japan
Author contributions: Sagami R, Nishikiori H and Ikuyama S designed the study and wrote the manuscript; Sagami R and Nishikiori H collected and analyzed the patient’s clinical data; and Murakami K made critical revisions to the article for important intellectual content.
Institutional review board statement: The Ethics Committee of Oita San-ai Medical Center approved this clinical study and the publication of this case report.
Informed consent statement: The patient involved in this case report authorized the disclosure of her protected health information for academic purposes.
Conflict-of-interest statement: All authors indicate that they have no financial interests or potential conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Ryota Sagami, MD, Department of Gastroenterology, Oita San-ai Medical Center, Oita 8701151, Japan.
Telephone: +81-975-411311 Fax: +81-975-415218
Received: June 9, 2017
Peer-review started: June 10, 2017
First decision: July 13, 2017
Revised: July 26, 2017
Accepted: August 15, 2017
Article in press: August 15, 2017
Published online: October 7, 2017
Core Tip

Core tip: Cystic or multiple pancreatic neuroendocrine tumors (pNETs) are very rare. This report describes a case of cystic pNET with multiple small tumors diagnosed from endoscopic ultrasonography (EUS) alone. Preoperative diagnosis was able to be obtained by EUS-guided fine needle aspiration biopsy. Postoperatively, 11 other micro-pNETs with multiple endocrine neoplasia type 1 were detected and cystic pNET morphologically changed to a small nodule because of suspected spontaneous rupture. Spontaneous rupture of cystic pNET has not been reported previously in the English literature.