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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2017; 23(31): 5680-5691
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5680
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5680
Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats
Kalliopi Despoudi, Ioannis Mantzoros, Orestis Ioannidis, Nikolaos Antoniou, Dimitrios Konstantaras, Savvas Symeonidis, Manousos George Pramateftakis, Efstathios Kotidis, Stamatis Angelopoulos, Konstantinos Tsalis, Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece
Aggeliki Cheva, Department of Pathology, General Hospital “G. Papanikolaou”, 57010 Thessaloniki, Greece
Author contributions: Despoudi K, Mantzoros I and Ioannidis O contributed equally to this work; Despoudi K, Pramateftakis MG, Angelopoulos S and Tsalis K designed coordinated the research; Despoudi K, Mantzoros I, Antoniou N, Konstantaras D and Symeonidis S performed the experiments; Despoudi K, Antoniou N, Konstantaras D, Pramateftakis MG and Kotidis E participated equally in treatment of animals; Despoudi K, Ioannidis O and Cheva A analysed the data; Despoudi K, Mantzoros I, Ioannidis O and Cheva A wrote the paper; Despoudi K, Mantzoros I, Ioannidis O, Cheva A, Antoniou N, Konstantaras D, Pramateftakis MG, Kotidis E, Angelopoulos S and Tsalis K significantly contributed to the linguistic formatting and correction of the manuscript, revised it critically for important intellectual content, and were responsible for final proof reading of the article.
Institutional review board statement: The study was reviewed and approved by the Faculty of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Veterinary Manager of the Prefecture of Thessaloniki [IACUC protocol number: (S.N.: 13/11872/11-09-08)].
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Orestis Ioannidis, MD, MSc, PhD, Surgeon, Scientific Fellow, Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Alexandrou Mihailidi 13, 54640 Thessaloniki, Greece. telonakos@hotmail.com
Telephone: +30-231-0814161 Fax: +30-231-0551301
Received: December 29, 2016
Peer-review started: December 30, 2016
First decision: February 13, 2017
Revised: June 8, 2017
Accepted: July 22, 2017
Article in press: July 24, 2017
Published online: August 21, 2017
Processing time: 233 Days and 10.5 Hours
Peer-review started: December 30, 2016
First decision: February 13, 2017
Revised: June 8, 2017
Accepted: July 22, 2017
Article in press: July 24, 2017
Published online: August 21, 2017
Processing time: 233 Days and 10.5 Hours
Core Tip
Core tip: The present study was designed to investigate the effect of local surgical adhesive glue composed of albumin/glutaraldehyde in the healing of colonic anastomoses in rats. The application of adhesive glue promotes the healing of colonic anastomoses in rats as it significantly increases the bursting pressure in the early period, but it also causes more adhesions and an enhanced inflammatory reaction.