Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice
Ching-Pin Lin, Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan
Ching-Pin Lin, Division of Gastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Wen-Chen Chuang, Fung-Jou Lu, Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chih-Yen Chen, Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
Chih-Yen Chen, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan
Author contributions: Lin CP and Chuang WC contributed equally to this work; Lin CP, Chuang WC, Lu FJ and Chen CY designed the research; Lin CP and Chuang WC performed the experiments and analyzed the data; Lu FJ contributed to the reagents, materials and analysis tools; Chen CY discussed the data and drafted the manuscript; Lin CP and Chuang WC wrote the manuscript.
Supported by a grant from the Chung Shan Medical University, No. CSMU0150011.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee, Chung-Shan Medical University (IACUC protocol number: 1745).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chih-Yen Chen, MD, PhD, Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road Taipei 112, Taiwan. chency@vghtpe.gov.tw
Telephone: +886-2-28712121-3763 Fax: +886-2-28711058
Received: February 28, 2017
Peer-review started: March 2, 2017
First decision: March 16, 2017
Revised: March 31, 2017
Accepted: June 18, 2017
Article in press: June 19, 2017
Published online: July 21, 2017
Processing time: 141 Days and 22.6 Hours
