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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2017; 23(25): 4624-4631
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4624
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4624
Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities
Guang-Lan Chen, Ye Zhang, Wang-Yue Wang, Xue-Liang Ji, Department of Gastroenterology, Lishui People’s Hospital, Lishui 323000, Zhejiang Province, China
Fei Meng, Pei-Song Xu, Ning-Min Yang, Department of Research Service, Zhiyuan Medical Inspection Institute Co., LTD, Hangzhou 310030, Zhejiang Province, China
Fu-Qiang Ye, Xiao-Chen Bo, Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, People’s Republic of China, Beijing 100089, China
Author contributions: Chen GL, Yang NM and Bo XC conceived the study; Zhang Y and Wang WY collected samples; Meng F and Xu PS performed the 16S rRNA sequencing; Ye FQ analyzed the data; Chen GL, Meng F and Xu PS wrote the paper; all authors contributed to this manuscript.
Supported by Lishui Science and Technology Bureau Research Fund , No. 2013JYZB43 ; and Medical and Health Science and Technology Plan Project of Zhejiang Province , No. 2015KYB371 .
Institutional review board statement: This study was approved by the Ethics Committee of Lishui People’s Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: To the best of our knowledge, no conflicts of interest exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Chen Bo, Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, People’s Republic of China, No. 27, Taiping Road, Haidian District, Beijing 100089, China. boxc@bmi.ac.cn
Telephone: +86-10-66931207 Fax: +86-10-66931207
Received: February 15, 2017
Peer-review started: February 16, 2017
First decision: April 7, 2017
Revised: April 10, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 7, 2017
Processing time: 141 Days and 20 Hours
Peer-review started: February 16, 2017
First decision: April 7, 2017
Revised: April 10, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 7, 2017
Processing time: 141 Days and 20 Hours
Core Tip
Core tip: To identify the influence on the gut microbial community between ulcerative colitis (UC) patients and their healthy partners, we investigated the gut bacterial community using 16S rRNA amplicon sequencing. The results showed that fecal microbial communities were more similar in UC patients, which had a lower relative abundance of Firmicutes bacteria. Microbiota dysbiosis was also founded in healthy partners. The pathways involved in lipid and nucleotide metabolism were more abundant in the UC patients. The membrane transport and metabolism of cofactors and vitamins pathways were significantly enriched in the healthy partners. Microbial composition might be affected in healthy partners cohabiting with UC patients.