Clinical Trials Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2017; 23(23): 4278-4284
Published online Jun 21, 2017. doi: 10.3748/wjg.v23.i23.4278
Potential application of neogalactosylalbumin in positron emission tomography evaluation of liver function
Shun-Da Du, Shao-Hua Li, Bao Jin, Zhao-Hui Zhu, Yong-Hong Dang, Hai-Qun Xing, Fang Li, Xue-Bing Wang, Xin Lu, Xin-Ting Sang, Hua-Yu Yang, Shou-Xian Zhong, Yi-Lei Mao
Shun-Da Du, Shao-Hua Li, Bao Jin, Xin Lu, Xin-Ting Sang, Hua-Yu Yang, Shou-Xian Zhong, Yi-Lei Mao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Shao-Hua Li, Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Zhao-Hui Zhu, Yong-Hong Dang, Hai-Qun Xing, Fang Li, Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Xue-Bing Wang, Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
Author contributions: Du SD, Zhu ZH, Li F, Wang XB, Sang XT, Zhong SX and Mao YL designed the research; Du SD, Li SH, Jin B, Zhu ZH, Dang YH, Xing HQ, Lu X and Yang HY performed the research; Dang YH, Xing HQ, Wang XB and Yang HY contributed new reagents/analytic tools; Du SD, Li SH, Zhu ZH, Li F, Lu X, Sang XT, Yang HY and Mao YL analyzed the data; Du SD, Li SH, Jin B, Zhu ZH, Yang HY and Mao YL wrote the paper.
Supported by National Natural Science Foundation of China, No. 30901453 and No. 81201566; National Key Technology Research and Development Program of China, No. BAI06B01; and Youth Grant of Peking Union Medical College Hospital.
Institutional review board statement: Animal Care and Use Committee of Peking Union Medical College Hospital.
Conflict-of-interest statement: All authors state that no conflicts of interest exist.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at yileimao@126.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Lei Mao, MD, PhD, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai-Fu-Yuan, Wangfujing, Beijing 100730, China. yileimao@126.com
Telephone: +86-10-69156042 Fax: +86-10-69156043
Received: August 27, 2016
Peer-review started: August 28, 2016
First decision: February 27, 2017
Revised: March 12, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: June 21, 2017
Processing time: 296 Days and 20.9 Hours
Core Tip

Core tip: Neogalactosylalbumin (NGA) is a specific ligand for asialoglycoprotein receptor that is exclusively expressed on the surface of hepatic parenchymal cells. This study showed [18F]FNGA mainly accumulated in liver and remained for sufficient time. Functionally-impaired liver showed a significant different uptake pattern of [18F]FNGA compared to controls.