Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2017; 23(23): 4191-4199
Published online Jun 21, 2017. doi: 10.3748/wjg.v23.i23.4191
Induction of chronic cholestasis without liver cirrhosis - Creation of an animal model
Felix Dondorf, René Fahrner, Michael Ardelt, Eleonora Patsenker, Felix Stickel, Uta Dahmen, Utz Settmacher, Falk Rauchfuß
Felix Dondorf, René Fahrner, Michael Ardelt, Uta Dahmen, Utz Settmacher, Falk Rauchfuß, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany
Eleonora Patsenker, Felix Stickel, Division of Gastroenterology and Hepatology, University Hospital Zürich, 8091 Zürich, Switzerland
Author contributions: Dondorf F, Settmacher U and Rauchfuß F designed the study; Dondorf F, Fahrner R, Patsenker E, Stickel F, Dahmen U and Rauchfuß F performed the data acquisition; Dondorf F, Settmacher U and Rauchfuß F analyzed the data; Dondorf F and Rauchfuß F wrote the paper; Fahrner R, Ardelt M, Settmacher U and Rauchfuß F revised the paper.
Institutional review board statement: Since this study is an animal research project, an institutional review board statement is not needed in our institution.
Institutional animal care and use committee statement: All animal experiments were approved by the Thuringian State Office of Food Safety and Consumer Protection (Department Consumer Protection, Veterinary and Pharmacy, Bad Langensalza, Germany). Protocol number: 02-039/12.
Conflict-of-interest statement: All authors have no conflicts of interest or financial ties to disclose.
Data sharing statement: The technical appendix and dataset are available from the corresponding author at felix.dondorf@med.uni-jena.de.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Falk Rauchfuß, MD, MSc, Department of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany. falk.rauchfuss@med.uni-jena.de
Telephone: +49-3641-9322601 Fax: +49-3641-9322602
Received: December 27, 2016
Peer-review started: December 28, 2016
First decision: February 10, 2017
Revised: February 27, 2017
Accepted: May 9, 2017
Article in press: May 9, 2017
Published online: June 21, 2017
Processing time: 174 Days and 15.3 Hours
Core Tip

Core tip: Animal research models mostly address either acute cholestasis or secondary biliary cirrhosis, neither of which reflect the clinical reality of central liver tumors with cholestatic liver damage without secondary liver cirrhosis. In this work, we present our data from a model simulating chronic cholestatic liver damage in an otherwise healthy liver.