Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2017; 23(13): 2404-2413
Published online Apr 7, 2017. doi: 10.3748/wjg.v23.i13.2404
Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?
Jing-Jing Lei, Li Zhou, Qi Liu, Can Xiong, Chun-Fang Xu
Jing-Jing Lei, Chun-Fang Xu, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Jing-Jing Lei, Li Zhou, Qi Liu, Can Xiong, Department of Gastroenterology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guiyan 550014, Guizhou Province, China
Author contributions: Lei JJ, Zhou L and Xu CF designed the study; Lei JJ, Liu Q and Xiong C participated in the acquisition of the clinical data; Lei JJ, Zhou L and Xu CF participated in the analysis and interpretation of the data; Lei JJ drafted the initial manuscript; Xu CF was the guarantor and revised the article critically for important intellectual content.
Supported by the Joint Foundation of Department of Science and Technology of Guizhou Province, China, No. [2016]7408.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, China.
Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicting interests related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chun-Fang Xu, Professor, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. xcf601@163.com
Telephone: +86-512-67780357 Fax: +86-512-65228072
Received: December 4, 2016
Peer-review started: December 6, 2016
First decision: January 10, 2017
Revised: January 28, 2017
Accepted: February 17, 2017
Article in press: February 17, 2017
Published online: April 7, 2017
Core Tip

Core tip: Mean platelet volume (MPV) is a machine-calculated measurement of average platelet size that is easily obtained using automatic blood count equipment at no additional cost and is often overlooked by clinicians. However, the relationship between MPV and acute pancreatitis (AP) remains unclear, and previous studies have been limited and produced conflicting results. In the present study, we demonstrated that the MPV was significantly lower in AP patients than in controls during the first three days after admission, particularly on day 1 after admission. Moreover, on day 1 of hospital admission, white blood cell count, lactate dehydrogenase and C-reactive protein measures were not as sensitive as MPV for predicting persistent organ failure in AP patients.