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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2017; 23(10): 1787-1795
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1787
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1787
Integrated analysis of microRNA and mRNA expression profiles in HBx-expressing hepatic cells
Ruo-Chan Chen, Juan Wang, Yong-Ming Fu, Yan Huang, Xue-Gong Fan, Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Xu-Yuan Kuang, Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Fang Peng, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Ning Li, Department of Blood Transfusion, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Author contributions: Li N and Fan XG designed the study and contributed equally to this work; Li N is a co-corresponding author of this article; Chen RC, Wang J, Kuang XY, Peng F, Fu YM and Huang Y collected and analyzed the data; Chen RC and Li N wrote the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Sciences Foundation of China , No. 81272253, No. 81502098 and No. 81670538 ; and the Special National International Technology Cooperation of China , No. 2015DFA31490 .
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: All data generated or analyzed during this study are included in this published article (and its supplementary information files).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xue-Gong Fan, MD, PhD, Professor of Infectious Disease, Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Disease, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha 410008, Hunan Province, China. xgfan@hotmail.com
Telephone: +86-13975163388
Received: November 15, 2016
Peer-review started: November 16, 2016
First decision: December 19, 2016
Revised: January 17, 2017
Accepted: February 16, 2017
Article in press: February 17, 2017
Published online: March 14, 2017
Peer-review started: November 16, 2016
First decision: December 19, 2016
Revised: January 17, 2017
Accepted: February 16, 2017
Article in press: February 17, 2017
Published online: March 14, 2017
Core Tip
Core tip: A number of miRNAs have been identified to be substantially involved in hepatocellular carcinoma cell proliferation, migration and invasion. Thus, an integrated analysis of the expression and function of miRNA and mRNA makes it possible to successfully identify the predicted miRNA-target network pattern and functional candidates of miRNA-mRNA pairs associated with HBx-related hepatocarcinogenesis.