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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2016; 22(9): 2771-2778
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2771
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2771
Inhibition of SW620 human colon cancer cells by upregulating miRNA-145
Chen Li, Yu-Qiang Li, Yu Wang, Biobank, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China
Na Xu, Department of Radiology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China
Zhi-Tu Zhu, Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China
Author contributions: Li C and Xu N contributed equally to this work; Li C, Xu N, Li YQ, Wang Y and Zhu ZT designed the research; Li C, Wang Y and Zhu ZT performed the research; Zhu ZT and Wang Y contributed new reagents/analytic tools; Li C, Wang Y and Li YQ analyzed the data; Li C, Xu N and Wang Y wrote the paper.
Supported by Liaoning Medical “Principal Fund” special fund clinical construction, No. XZJJ20130214; and Liaoning Provincial Science and Technology Department of Science and Technology Program, No. 2013225305.
Institutional review board statement: This study was approved by the Ethics Committee of the First Affiliated Hospital of Liaoning Medical University.
Institutional animal care and use committee statement: All procedures in this study involving animals met the requirements of the ethics of animal experimentation and were approved by Laboratory Animal Ethics Committee of the First Affiliated Hospital of Liaoning Medical University.
Conflict-of-interest statement: The authors have no conflict of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Tu Zhu, MD, Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, No. 2, Wuduan, Renmin Street, Jinzhou 121001, Liaoning Province, China. zhuzhitu2014jz@hotmail.com
Telephone: +86-416-4605040 Fax: +86-416-4605067
Received: April 23, 2015
Peer-review started: April 24, 2015
First decision: July 10, 2015
Revised: August 31, 2015
Accepted: December 1, 2015
Article in press: December 1, 2015
Published online: March 7, 2016
Processing time: 314 Days and 1.9 Hours
Peer-review started: April 24, 2015
First decision: July 10, 2015
Revised: August 31, 2015
Accepted: December 1, 2015
Article in press: December 1, 2015
Published online: March 7, 2016
Processing time: 314 Days and 1.9 Hours
Core Tip
Core tip: miRNA-145 (miR-145) may play an important role in inhibiting colon cancer proliferation and invasive migration. This finding lays a good foundation for further investigation of targeting miR-145 as a tumor suppressor in colon cancer treatment, and provides novel evidence for the anti-cancer effects and therapeutic potential of miR-145.