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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2016; 22(9): 2760-2770
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2760
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2760
Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion
Joep Grootjans, Kaatje Lenaerts, Cornelis HC Dejong, Joep PM Derikx, Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands
Joep Grootjans, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
Wim A Buurman, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands
Author contributions: Grootjans J and Derikx JPM wrote the manuscript; Grootjans J, Lenaerts K, Buurman WA, Dejong CHC and Derikx JPM provided important intellectual contribution to the manuscript.
Supported by Dutch Gastroenterology and Hepatology Society (MLDS grant WO10-57 to Dejong CHC and Lenaerts K); Career Development Grant CDG (to Derikx JPM); and The Netherlands Organisation for Scientific Research (Rubicon grant 825.13.012 to Grootjans J).
Conflict-of-interest statement: No conflicts of interest exist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Joep Grootjans, MD, PhD, Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands. j.grootjans@maastrichtuniversity.nl
Telephone: +31-43-3881497 Fax: +31-43-3884154
Received: June 22, 2015
Peer-review started: June 25, 2015
First decision: July 14, 2015
Revised: September 24, 2015
Accepted: December 14, 2015
Article in press: December 14, 2015
Published online: March 7, 2016
Processing time: 254 Days and 9.8 Hours
Peer-review started: June 25, 2015
First decision: July 14, 2015
Revised: September 24, 2015
Accepted: December 14, 2015
Article in press: December 14, 2015
Published online: March 7, 2016
Processing time: 254 Days and 9.8 Hours
Core Tip
Core tip: To improve our knowledge on the pathophysiology of human intestinal ischemia-reperfusion (IR), a new human experimental model was developed in recent years. In the current review, we overview and discuss the most important new insights on intestinal IR in man.