Cheng SX. Calcium-sensing receptor: A new target for therapy of diarrhea. World J Gastroenterol 2016; 22(9): 2711-2724 [PMID: 26973410 DOI: 10.3748/wjg.v22.i9.2711]
Corresponding Author of This Article
Sam Xianjun Cheng, MD, PhD, Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, University of Florida, 1600 SW Archer Road, RG 120, PO Box 100296, Gainesville, FL 32610, United States. sam.cheng@ufl.edu
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 7, 2016; 22(9): 2711-2724 Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2711
Calcium-sensing receptor: A new target for therapy of diarrhea
Sam Xianjun Cheng
Sam Xianjun Cheng, Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610, United States
Author contributions: Cheng SX contributes all to this work.
Supported by The National Institute of Health NICHD, award No. K08HD079674; the CDNHF/NASPGHAN foundation, award No. 00102979, and the Children’s Miracle Network.
Conflict-of-interest statement: The author declares no conflicts of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sam Xianjun Cheng, MD, PhD, Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, University of Florida, 1600 SW Archer Road, RG 120, PO Box 100296, Gainesville, FL 32610, United States. sam.cheng@ufl.edu
Telephone: +1-352-2739358 Fax: +1-352-2948062
Received: October 13, 2015 Peer-review started: October 14, 2015 First decision: November 13, 2015 Revised: November 18, 2015 Accepted: December 8, 2015 Article in press: December 8, 2015 Published online: March 7, 2016 Processing time: 141 Days and 4.2 Hours
Core Tip
Core tip: Diarrheal disease remains a leading cause of death in children and the elderly throughout the world. The cause of death is dehydration secondary to severe diarrhea. Intestinal calcium-sensing receptor (CaSR) is a newly uncovered ancient antidiarrheal receptor system that appears to exert profound effects not only on intestinal secretion, absorption and motility but also on gut permeability and inflammatory responses. Activating this unusual machinery reverses pathophysiological changes of both secretory and inflammatory diarrheas. Considering its unique property of using simple nutrients as activators, it is now possible that through targeting of CaSR and developing novel oral rehydrating solutions that are inexpensive and practical to use in all countries, these diarrhea-associated deaths are reduced or eliminated.
