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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2016; 22(8): 2592-2600
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2592
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2592
Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease
Myong Ki Baeg, Seung Kew Yoon, Sun-Hye Ko, Yong-Sun Noh, In-Seok Lee, Myung-Gyu Choi, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul 137-701, South Korea
Author contributions: Baeg MK and Ko SK designed the research; Baeg MK and Noh YS performed the research; Ko SK and Lee IS analyzed the data; Baeg MK, Yoon SK and Ko SK wrote the manuscript; Yoon SK, Lee IS and Choi MG edited the manuscript.
Institutional review board statement: This study was reviewed and approved by Seoul St. Mary’s Hospital Institutional Review Board, No. KC12RISI0317.
Informed consent statement: No consent statements were needed in carrying out this manuscript as this was a retrospective study using blinded records. The Institutional Review Board of The Catholic Medical Center approved the waiving of informed consent forms.
Conflict-of-interest statement: No conflicts of interest were reported for all authors.
Data sharing statement: The original, blinded data are available from the corresponding author at yoonsk@catholic.ac.kr.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seung Kew Yoon, MD, PhD, Department of Internal Medicine, The Catholic University of Korea College of Medicine, 222 Banpodaero, Seochogu, Seoul 137-701, South Korea. yoonsk@catholic.ac.kr
Telephone: +82-2-22587534 Fax: +82-2-5369559
Received: October 3, 2015
Peer-review started: October 5, 2015
First decision: November 5, 2015
Revised: November 22, 2015
Accepted: December 12, 2015
Article in press: December 14, 2015
Published online: February 28, 2016
Processing time: 145 Days and 0.1 Hours
Peer-review started: October 5, 2015
First decision: November 5, 2015
Revised: November 22, 2015
Accepted: December 12, 2015
Article in press: December 14, 2015
Published online: February 28, 2016
Processing time: 145 Days and 0.1 Hours
Core Tip
Core tip: Nonalcoholic fatty liver disease (NAFLD) is a common disorder which affects 20%-45% of the general population. Helicobacter pylori (H. pylori) infection has been suggested as a contributing to NAFLD. We investigated the association between H. pylori infection and NAFLD by using two non-invasive scoring formula, NAFLD-fat score and hepatic steatosis index. Our study showed that H. pylori infection was not a risk factor for NAFLD by either formula. However, c-reactive protein and smoking were significant risk factors for NAFLD. Prospective studies involving liver biopsies should be carried out to further investigate the association between H. pylori infection and NAFLD.