Topic Highlight
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2016; 22(8): 2434-2440
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2434
Emerging molecular basis of hematogenous metastasis in gastric cancer
Jing Zhong, Yan Chen, Liang-Jing Wang
Jing Zhong, Yan Chen, Liang-Jing Wang, Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine and Institute of Gastroenterology, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Author contributions: Zhong J and Chen Y contributed to the literature searching and the writing of the manuscript; Wang LJ contributed to the original idea, polishing and final proof of the manuscript.
Supported by National Natural Science Foundation of China, No. 81472214 and No. 81302070; Science and Technology Innovation Team Fund of Zhejiang Province, No. 2013TD13; Natural Science Foundation of Zhejiang Province, No. LY13H160019; and Science and Technology Fund of Zhejiang Province, No. 2012C37105.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Liang-Jing Wang, Professor, Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. wanglj76@hotmail.com
Telephone: +86-571-87783715 Fax: +86-571-86006788
Received: April 28, 2015
Peer-review started: May 7, 2015
First decision: October 14, 2015
Revised: October 29, 2015
Accepted: November 19, 2015
Article in press: November 19, 2015
Published online: February 28, 2016
Processing time: 302 Days and 20.4 Hours
Core Tip

Core tip: The premetastatic niche is a novel predictor of cancer metastasis. The following steps including local invasion, intravasation into vessel lumen, survival in the circulation and extravasation also contribute to gastric cancer progression through a variety of mechanisms. This review provides an overview of the complex interaction between tumors and their microenvironment in hematogenous metastasis cascade.