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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2016; 22(6): 2133-2141
Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.2133
Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.2133
Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation
Jiu-Lin Song, Wei Gao, Yan Zhong, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Bo Li, Wen-Tao Wang, Hong Wu, Ming-Qing Xu, Zhe-Yu Chen, Yong-Gang Wei, Li Jiang, Jian Yang, Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yan LN and Song JL conceived and designed the study; Song JL, Gao W, and Zhong Y analyzed the data; Song JL and Gao W drafted the manuscript; Yan LN and Yang JY revised the manuscript and obtained funding; Li B, Wen TF, Yang JY, Xu MQ, Wang WT, Chen ZY, Wei YG, Jiang L and Yang J acquired data, provided technical support, and edited the manuscript; all authors have read and approved the final version to be published.
Supported by Key Technology Support Program of Sichuan Province, No. 2013SZ0023.
Institutional review board statement: This study was approved by West China Hospital Ethics Committee, Chengdu, China.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at yanlunan688@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lu-Nan Yan, MD, Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. yanlunan688@163.com
Telephone: +86-28-85422867 Fax: +86-28-85422867
Received: September 17, 2015
Peer-review started: September 17, 2015
First decision: October 14, 2015
Revised: October 26, 2015
Accepted: November 19, 2015
Article in press: November 19, 2015
Published online: February 14, 2016
Peer-review started: September 17, 2015
First decision: October 14, 2015
Revised: October 26, 2015
Accepted: November 19, 2015
Article in press: November 19, 2015
Published online: February 14, 2016
Core Tip
Core tip: New-onset diabetes mellitus (NODM) is a common and severe metabolic complication that develops after liver transplantation. It is more prominent in recipients with tacrolimus (TAC)-dominant regimens. In this study, we found that the incidence of NODM is TAC concentration (cTAC)-dependent. Using a receiver operating characteristic curve, we identified that a cutoff cTAC of 5.89 ng/mL was predictive of NODM development after 6 mo after LT. And recipients exposed to low mean cTAC developed less other TAC related complications. The strategy of maintaining cTAC below 5.89 ng/mL after 6 mo after LT is therefore safe and beneficial.