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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2016; 22(6): 1953-1965
Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.1953
Hepatitis C virus relies on lipoproteins for its life cycle
Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi
Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
Giorgia Di Caprio, Marco Tripodi, Department of Cellular Biotechnologies and Hematology, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, 00149 Rome, Italy
Gian Maria Fimia, Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, Italy
Author contributions: All authors made substantial contributions to analysis and interpretation of data, drafting the article or making critical revisions related to important intellectual content; and gave final approval of the version of the article.
Supported by AIRC (to Tripodi M; No. IG-13529 to Fimia GM); Ministry for Health of Italy (“Ricerca Corrente” to Grassi G, Tripodi M, Alonzi T, Fimia GM and Ippolito G; “Ricerca Finalizzata” to Fimia GM and Ippolito G); Ministry of University and Research of Italy (PRIN to Tripodi M; PhD program to Di Caprio G).
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tonino Alonzi, PhD, UOSD Gene Expression and Experimental Hepatology, National Institute for Infectious Diseases “L. Spallanzani” IRCCS. Via Portuense 292, 00149 Rome, Italy. tonino.alonzi@inmi.it
Telephone: +39-6-55170909 Fax: +39-6-5582825
Received: August 25, 2015
Peer-review started: August 26, 2015
First decision: September 29, 2015
Revised: October 19, 2015
Accepted: December 19, 2015
Article in press: December 21, 2015
Published online: February 14, 2016
Processing time: 150 Days and 19.3 Hours
Core Tip

Core tip: The aim of the review is to summarize current knowledge concerning the interplay between hepatitis C virus (HCV) and lipoprotein metabolism. In particular, the manuscript discusses the role played by members of lipoproteins family in all steps of HCV life cycle.